Disadvantages of Controlled Drug Release:
The potential disadvantages of controlled-release drugs include the possibility of dosing, less ease of administration of the dose, increased likelihood of metabolism of the first hepatic passage, the potential for delayed start-up, the potential for reduced systemic availability and reduction of drug release time in the optimal absorption areas of the gastrointestinal tract.
Dumping, or the rapid release of the drug is important for potent drugs that have a narrow therapeutic index. Good manufacturing practices (GMP) are less likely to occur. The soft (fine) softening is often difficult in the controlled release formulas. It is possible to divide the fixed-release discs using the granule matrix to reduce the dose, but repeat action tablets or osmotic pump devices lose their fixed-release properties as soon as the pellet disintegrates. Elevation of hepatic I metabolism may occur with liver-filtered drugs, but only if hepatic filtration is satisfied after rapid absorption of normal dosage forms. Decreased systemic availability is common in fixed-dosage forms and standard availability is 80-85% of normal preparations. The time in the gastrointestinal tract is a potential disadvantage of orally controlled oral products, which distinguishes oral form from other forms of controlled release (eg, skin adhesives that can provide slow release of the drug for a long time).
The potential disadvantages of controlled-release drugs include the possibility of dosing, less ease of administration of the dose, increased likelihood of metabolism of the first hepatic passage, the potential for delayed start-up, the potential for reduced systemic availability and reduction of drug release time in the optimal absorption areas of the gastrointestinal tract.
Dumping, or the rapid release of the drug is important for potent drugs that have a narrow therapeutic index. Good manufacturing practices (GMP) are less likely to occur. The soft (fine) softening is often difficult in the controlled release formulas. It is possible to divide the fixed-release discs using the granule matrix to reduce the dose, but repeat action tablets or osmotic pump devices lose their fixed-release properties as soon as the pellet disintegrates. Elevation of hepatic I metabolism may occur with liver-filtered drugs, but only if hepatic filtration is satisfied after rapid absorption of normal dosage forms. Decreased systemic availability is common in fixed-dosage forms and standard availability is 80-85% of normal preparations. The time in the gastrointestinal tract is a potential disadvantage of orally controlled oral products, which distinguishes oral form from other forms of controlled release (eg, skin adhesives that can provide slow release of the drug for a long time).