Showing posts with label Atypical neuroleptic. Show all posts
Showing posts with label Atypical neuroleptic. Show all posts

ABILIFY MAINTENA RANGE OF MEDICINES

 Drug family: Atypical neuroleptic

WHAT IS ABILIFY MAINTENA PRESCRIBED FOR?

This drug is an “atypical” neuroleptic . Some of its side effects are less marked than those of conventional neuroleptics . It has antipsychotic properties.

It is used in the maintenance treatment of schizophrenia .

You can consult the following article(s):

  • Schizophrenia and other psychoses

PRESENTATIONS OF THE DRUG ABILIFY MAINTENA

ABILIFY MAINTENA 300 mg : preparation for prolonged-release  suspension for injection  ; 1 vial of powder and 1 vial of solvent
On prescription (List I) - Reimbursable at 65% -  Price:  €238.33 .
ABILIFY MAINTENA 400 mg : preparation for prolonged-release  suspension for injection  ; 1 pre-filled syringe
On prescription (List I) - Reimbursable at 65% -  Price:  €238.33 .

The prices mentioned do not take into account the pharmacist's " dispensing fees ".

COMPOSITION OF THE DRUG ABILIFY MAINTENA

p flsyringe
Aripiprazole300 mg400 mg
Common excipients : Carmellose sodium, Water ppi, Mannitol , Sodium dihydrogen phosphate monohydrate, Sodium hydroxide
Other excipient (specific to certain forms): Rubber

ATTENTION

This medicinal product should be used in patients whose disease is well controlled by oral treatment with aripiprazole and who have tolerated it well.

In the event of an unexplained fever associated with muscle stiffness (which could be due to the drug), do not continue treatment without medical advice: risk of neuroleptic malignant syndrome .

Precautions are necessary in case of history of convulsions , diabetes , cardiovascular disease ( history of myocardial infarction , heart failure or heart rhythm disorders ), cerebrovascular disease , hypotension or arterial hypertension and in the elderly.

Avoid alcoholic beverages: increased risk of drowsiness.

Given its potential adverse effects , this medication may not be compatible with driving or operating dangerous machinery in some people. Make sure on the occasion of the first catches that you tolerate this medicine well before driving or using a machine.

INTERACTIONS OF THE DRUG ABILIFY MAINTENA WITH OTHER SUBSTANCES

Medicines containing the following substances are likely to modify the efficacy of the treatment: carbamazepine, phenobarbital, phenytoin, primidone, griseofulvin, rifabutin, rifampicin, St. John's wort, ketoconazole, itraconazole, quinidine, fluoxetine, paroxetine, antiproteases .

Tell your doctor or pharmacist if you are taking an antihypertensive or other sedatives ( tranquilizers , sleeping pills , certain cough or pain medications containing opiates , antidepressants , neuroleptics , etc.).

FERTILITY, PREGNANCY AND LACTATION

PREGNANCY :

The effect of this medicine during pregnancy is not well known: only your doctor can assess the possible risk of its use in your case.

FEEDING WITH MILK :

This medication passes into breast milk; a choice is therefore necessary between breastfeeding and taking the drug. This decision should be made in consultation with your doctor.

INSTRUCTIONS FOR USE AND DOSAGE OF THE DRUG ABILIFY MAINTENA

This medicine is injected intramuscularly into the gluteal muscle or into the shoulder.

The suspension for injection is prolonged-release : the active substance is released slowly, over several weeks.

USUAL DOSE:

  • Adult over 18 years old : 1 injection per month.

TIPS

After the first injection, treatment with ariprazole tablets should be continued for 2 weeks.

In the treatment of schizophrenia and other psychoses , neuroleptics provide effective control of the disease, but modifying or stopping treatment inadvertently exposes you to a serious relapse.

Weight gain may be observed during treatment. A balanced diet, and if necessary the advice of a nutritionist, can prevent and limit this phenomenon.

POSSIBLE SIDE EFFECTS OF THE DRUG ABILIFY MAINTENA

Pain at injection site.

Common: dizziness, agitation, anxiety, impatience, insomnia, drowsiness, involuntary or inappropriate movements, tremor, inability to sit still, headache, fatigue, dry mouth, weight gain, heart rhythm disturbances , orthostatic hypotension or, on the contrary, hypertension .

Uncommon: depression , nausea, vomiting, indigestion, cough, libido disorder, vision disorders, muscle stiffness, acne , eczema , milk flow from the nipple, vaginal dryness, increased transaminases .

Compulsive behavioral disorders ( gambling addiction ) have been reported under treatment. In the event of the occurrence of such disorders, do not hesitate to speak to your doctor as soon as possible.

ABILIFY RANGE OF MEDICINES

 Drug family: Atypical neuroleptic

WHAT IS ABILIFY PRESCRIBED FOR?

This drug is an “atypical” neuroleptic . Some of its side effects are less marked than those of conventional neuroleptics . It has antipsychotic properties.

He is used :
  • in the treatment of schizophrenia ,

  • in the context of bipolar disorder to treat manic episodes and to prevent recurrences.

You can consult the following article(s):

  • Schizophrenia and other psychoses
  • Bipolar disorders

ABILIFY DRUG PRESENTATIONS

ABILIFY 5 mg  : tablet (blue); box of 28
On prescription (List I) - Reimbursable at 65% -  Price:  €23.83 .
ABILIFY 10 mg  : tablet (pink); box of 28
On prescription (List I) - Reimbursable at 65% -  Price:  €23.83 .
ABILIFY 10 mg  : orodispersible tablet (pink; vanilla flavor); box of 28
On prescription (List I) - Reimbursable at 65% -  Price:  €23.83 .
ABILIFY 15 mg  : tablet (yellow); box of 28
On prescription (List I) - Reimbursable at 65% -  Price:  €23.83 .
ABILIFY 15 mg  : orodispersible tablet (yellow; vanilla flavor); box of 28
On prescription (List I) - Reimbursable at 65% -  Price:  €23.83 .
ABILIFY 1 mg/ml  : oral solution (orange flavoring); 150 ml bottle with graduated dosing system
On prescription (List I) - Reimbursable at 65% -  Price:  €44.12 .

The prices mentioned do not take into account the pharmacist's " dispensing fees ".

COMPOSITION OF THE DRUG ABILIFY

p cpp cpp cp orodisp
Aripiprazole5mg10mg10mg
Lactose67mg62mg
Aspartame+
p cpp cp orodispp ml
Aripiprazole20mg20mg1mg
Lactose57mg
Aspartame+
Glucose400mg
Parabens+
No common excipient .

ATTENTION

In the event of an unexplained fever associated with muscle stiffness (which could be due to the drug), do not continue treatment without medical advice: risk of neuroleptic malignant syndrome .

Precautions are necessary in case of diabetes , epilepsy , heart disease ( old or recent myocardial infarction , angina pectoris , heart failure , heart rhythm disorders ), abnormal blood pressure , risk of thrombosis , difficulty in swallowing, history of addiction to gambling, dementia in an elderly person, phenylketonuria ( orodispersible tablet : presence of aspartame).

In case of significant weight gain, appearance of abnormal or involuntary movements, marked drowsiness during the day, contact your doctor without delay. A change in treatment may be considered.

Avoid alcoholic beverages: increased risk of drowsiness.

Given its potential adverse effects , this medication may not be compatible with driving or operating dangerous machinery in some people. Make sure on the occasion of the first catches that you tolerate this medicine well before driving or using a machine.

INTERACTIONS OF THE DRUG ABILIFY WITH OTHER SUBSTANCES

Medicines containing the following substances are likely to modify the efficacy of the treatment: carbamazepine, phenobarbital, phenytoin, primidone, griseofulvin, rifabutin, rifampicin, St. John's wort, ketoconazole, itraconazole, quinidine, fluoxetine, paroxetine, antiproteases .

Tell your doctor or pharmacist if you are taking an antihypertensive , other sedatives ( tranquilizers , sleeping pills ) or an antidepressant .

FERTILITY, PREGNANCY AND LACTATION

PREGNANCY :

The effect of this medicine during pregnancy is not well known: only your doctor can assess the possible risk of its use in your case.

FEEDING WITH MILK :

This medication passes into breast milk: breastfeeding is not recommended during treatment.

INSTRUCTIONS FOR USE AND DOSAGE OF THE DRUG ABILIFY

This medication is taken once a day, at the same time of day, with or without food.

Orodispersible tablets are to be placed directly on the tongue, with or without water. They can also be dissolved beforehand in a little water.

The oral solution should be taken as it is, without being diluted in liquid or mixed with food.

USUAL DOSE:

In the treatment of schizophrenia :

  • Adult over 18 years old : 10 to 15 mg per day. The maximum dose should not exceed 30 mg per day.

  • Adolescent over 15 years old : 10 mg per day. This dosage is obtained by using the oral solution to gradually increase the dose.

In the treatment of manic episodes :
  • Adult over 18 years old : 15 mg per day. For the prevention of recurrences of manic episodes , treatment is maintained at the same dose for a period set by the doctor.

  • Adolescent over 13 years old : the starting dose is 2 mg per day (using the oral solution) and is gradually increased to 10 mg per day. The duration of treatment should be as short as necessary to control symptoms and should not exceed 12 weeks.

TIPS

In the treatment of schizophrenia and other psychoses , neuroleptics provide effective control of the disease, but modifying or stopping treatment inadvertently exposes you to a serious relapse.

The oral solution should not be stored for more than 6 months after opening the bottle. Remember to note the date of first use on the packaging or on the bottle.

POSSIBLE SIDE EFFECTS OF THE DRUG ABILIFY

Common (less than 1 in 10 people): headache, fatigue, nausea, vomiting, difficulty digesting, constipation , excessive salivation, dizziness, insomnia, agitation, anxiety, drowsiness, involuntary movements, tremor and blurred vision.

Uncommon (less than 1 in 100 people): orthostatic hypotension (feeling dizzy when standing up), depression .

Adverse effects reported after marketing, of unknown frequency: palpitations , onset or worsening of diabetes , weight gain, anorexia , nervousness, addiction to gambling, suicidal thoughts (inherent to the disease), slurred speech , rash , excessive sweating, cramps, muscle stiffness or pain, weakness, difficulty urinating, priapism , swelling of the hands, ankles or feet, convulsions , malaise, high blood pressure , thromboembolic accident, swallowing disorders with risk of food sniffing ,inflammation of the pancreas, hepatitis , allergic reaction , abnormal blood count , low sodium level in the blood.