RANGE OF ACTISKENAN DRUGS
Drug family: Fast-acting morphine
IN WHICH CASE IS THE DRUG ACTISKENAN PRESCRIBED?
This medication is a powerful painkiller that contains morphine . It fights pain by acting directly on the brain. It acts quickly but its effect fades in a few hours.
It is used in the treatment of intense or stubborn pain, in particular cancer pain.
You can consult the following article(s):
- Pain in adults
- pain in children
PRESENTATIONS OF THE DRUG ACTISKENAN
The prices mentioned do not take into account the pharmacist's " dispensing fees ".
COMPOSITION OF THE DRUG ACTISKENAN
| p gel | p gel | |
| Morphine sulphate | 5mg | 10mg |
| Azorubin | + | + |
| Sucrose | + | + |
| p gel | p gel | |
| Morphine sulphate | 20mg | 30mg |
| Sucrose | + | + |
CONTRAINDICATIONS OF THE DRUG ACTISKENAN
severe respiratory failure ;
severe liver failure ;
epilpesia not stabilized by treatment;
recent head trauma;
bowel obstruction ;
in combination with medicines containing buprenorphine, nalbuphine, pentazocine, naltrexone, nalmefene or sodium oxybate ;
child under 6 months;
breast- feeding (in case of initiation of treatment or prolonged treatment).
ATTENTION
This strong opioid drug poses a risk of addiction . The risk is higher in case of prolonged use or exceeding the prescribed dosage in the face of a decline in the effect of the drug (tolerance). The prescribed dose should never be exceeded without further medical advice.
A gradual reduction in doses is necessary after prolonged treatment to limit withdrawal symptoms ( withdrawal syndrome ) which may be observed in the event of abrupt cessation of treatment.
Precautions are necessary in case of a history of drug addiction or alcoholism, renal insufficiency , intracranial hypertension , sickle cell disease , severe chronic asthma or bronchitis, hypothyroidism and in the elderly, especially in the case of adenoma of the prostate .
Avoid drinking alcoholic beverages during treatment.
This medication can induce sometimes intense drowsiness in some people. This drowsiness can be increased by taking alcohol or other sedative drugs . Driving or using dangerous machinery is not recommended.
Athlete: this medicine contains a substance likely to make certain anti- doping tests positive .
INTERACTIONS OF THE DRUG ACTISKENAN WITH OTHER SUBSTANCES
medicines containing pentazocine, nalbuphine, buprenorphine ( TEMGÉSIC , SUBUTEX and its generics ), naltrexone or nalmefene: decrease in the analgesic effect of morphine ;
with sodium oxybate : increased risk of respiratory depression .
It may interact with drugs containing rfampicin.
Also inform your doctor if you are taking sedative medication ( tranquilizers , sleeping pills , antidepressants , neuroleptics , etc.); they may increase the risk of drowsiness or respiratory depression .
FERTILITY, PREGNANCY AND LACTATION
PREGNANCY :
respiratory failure may occur in the newborn of a mother treated with high doses, even if the treatment is punctual but shortly before delivery;
a withdrawal syndrome , on the other hand, can affect newborns if their mother receives regular treatment, even at low doses. The child then suffers from irritability, vomiting, and even convulsions .
It is therefore important to inform the obstetrician of any opioid intake , so that these risks can be prevented by monitoring and any appropriate treatment.
FEEDING WITH MILK :
Morphine passes into breast milk: breast-feeding is contraindicated in the event of prolonged treatment. A single take is not a problem.
INSTRUCTIONS FOR USE AND DOSAGE OF THE DRUG ACTISKENAN
The capsules should not be swallowed whole with a little water. For children under 6 and people who have difficulty swallowing the capsules, they can be opened and their contents mixed with semi-liquid foods (puree, yoghurt, etc.) or administered using a a gastric tube.
USUAL DOSE:
Adults and children over 6 months : the dosage , strictly individual, is gradually adapted by the doctor according to the intensity of the pain and any associated medications. The daily dose is generally divided into 6 doses, most often equivalent, 4 hours apart. This immediate-release form can also be used to supplement the action of prolonged - release morphine analgesics .
TIPS
Morphine and related drugs are not just for cancer pain; they are also used in the short-term treatment of severe pain that may follow a fracture, surgery, myocardial infarction , etc.
Follow the dosage and duration of treatment prescribed by your doctor. But if the treatment seems insufficient, do not hesitate to contact him again.
Special prescription conditions:
The prescription for morphine and related substances ( narcotics ) is written by the doctor on a secure prescription.
The period of validity of the prescription is limited to 28 days.
POSSIBLE SIDE EFFECTS OF THE DRUG ACTISKENAN
Very common: nausea which often resolves spontaneously, constipation which requires regular laxative treatment.
Common: vomiting, decreased appetite, dry mouth, confusion of thoughts, insomnia, dizziness, headache, involuntary muscle contractions, drowsiness, excessive sweating (hyperhidrosis), skin rash , itching, fatigue, malaise.
Uncommon: agitation, excitation, hallucinations, tingling or numbness of the extremities, hypotension , intestinal obstruction, taste disturbance, difficult digestion, urinary retention, hives , increased transaminases .
Undetermined frequency: nightmares (especially in the elderly), difficulty urinating, intracranial hypertension , decreased libido, impotence , absence of menstruation, sleep-related respiratory disorders, adrenal insufficiency .
Respiratory depression , especially when combined with benzodiazepines or other sedative drugs . Contact your doctor urgently if you have difficulty breathing, wheezing or severely slowed breathing.
Suddenly stopping this medication can also lead to a withdrawal syndrome : panic attack , significant anxiety, irritability, chills, dilation of the pupils , hot flushes, sweating, abdominal or joint pain. These symptoms can be avoided by gradually reducing the doses.
What is 10mg 1ml morphine sulfate?
Morphine Sulfate 10mg/ml Solution for Injection is authorised for the relief of severe pain (see SmPC for the full indication). It contains Morphine Sulfate as the active substance and it is given by 10mg in 1ml Solution for Injection.
What is the half-life of SC morphine?
Half-life:
Serum half-life in the period 10 minutes to 6 hours following intravenous administration, 2 to 3 hours; serum half-life in the period 6 hours onwards, 10 to 44 hours.
What is the conversion of oral morphine to sub cut?
The oral to subcutaneous potency ratio of morphine is between 1:2 and 1:3 (that is, the subcutaneous dose is one third to one half of the oral dose). In practice, most centres divide the oral dose by two and re-titrate as necessary.
What is morphine sulphate injection oral?
Morphine sulfate injection is indicated for the relief of moderate to severe pain. Morphine sulfate injection is used especially in pain associated with cancer, myocardial infarction and surgery. Morphine also helps to relieve the anxiety and insomnia which may be associated with severe pain.
How much is 20mg morphine?
Brand names for morphine include Infumorph, Duramorph PF, and Mitigo. The cost for morphine oral concentrate (20 mg/mL) is around $13 for a supply of 15 milliliters, depending on the pharmacy you visit. Quoted prices are for cash-paying customers and are not valid with insurance plans.
What is morphine 20 mg per mL?
Morphine sulfate oral solution 100 mg per 5 mL (20 mg/mL) is an opioid analgesic indicated for the relief of moderate to severe acute and chronic pain in opioid-tolerant patients.
Is tramadol stronger than codeine?
Official answer. Both tramadol and codeine are prescription opioid painkillers, and they seem to be equally effective in terms of pain relief. There is no evidence that tramadol is any stronger than codeine at relieving pain.
Can you cut a 30 mg morphine in half?
Swallow morphine sulfate extended-release tablets whole. Do not cut, break, chew, crush, dissolve, snort, or inject morphine sulfate extended-release tablets because this may cause you to overdose and die.
What is morphine 20mg used for?
Morphine tablet is used to relieve short-term (acute) or long-term (chronic) moderate to severe pain.
What's the highest mg of morphine sulfate?
Morphine sulfate extended-release capsules, USP are an opioid analgesic supplied in 20 mg, 30 mg, 50 mg, 60 mg, 80 mg, and 100 mg strengths for oral administration.
Is 20 mg of oral morphine a lot?
This product is very strong. It should only be used if you have been regularly taking moderate to large amounts of an opioid pain medication. This strength may cause overdose (even death) if taken by a person who has not been regularly taking opioids. Each milliliter of this product contains 20 milligrams of morphine.
