It all starts with a blockage of the cellular response to danger
According to the US National Institutes of Health (NIH), chronic diseases cause more than half of deaths worldwide. This new theory on the pathogenesis of chronic diseases, developed in the specialized journal Mitochondrion by a team from the University of California – San Diego, opens up new therapeutic perspectives: the pathogenesis of these chronic diseases, such as cancer, diabetes and certain neurological, would be triggered by a lack or deficiency of cellular communication resulting in a blockage of the natural healing cycle. This blockage would be induced by the dysfunction of two main agents: the mitochondria, these cellular power stations and the metabokines, metabolic signaling molecules allowing to regulate the cellular receptors,
Until recent years – when the epidemic of chronic diseases exploded – modern medicine was more concerned with acute conditions and injuries, from physical injuries to infections, from heart attacks to asthma attacks. According to these experts at the University of California at San Diego School of Medicine, progress in the treatment of chronic diseases has meanwhile lagged. A dramatic delay, while the US Centers for Disease Control and Prevention (CDC) estimate that more than half of adults and a third of children and adolescents in rich countries live with at least one chronic disease. Dr. Robert K. Naviaux, Professor of Medicine,
The healing process is a dynamic cycle :
it begins with an injury and ends with healing. The molecular characteristics of this healing process are universal: most chronic diseases are caused by the biological reaction to injury, not by the original injury or by the agent of injury. Illness occurs because the body is unable to carry out and complete the healing process. Hence the chronic nature of the disease. Progressive dysfunction with recurrent injury after incomplete healing occurs in all organ systems, so in chronic disease cells are caught in a repeated loop of incomplete recovery and “re-injury” or recurrence, unable to heal completely. Some examples :
melanoma: this deadly form of skin cancer can be caused by sun exposure decades before, which damaged DNA, which was never repaired;
post-traumatic stress disorder (PTSD): this can appear months or years after a concussion.
This biology underlies almost all known chronic diseases, including susceptibility to recurrent infections, autoimmune diseases such as rheumatoid arthritis, heart, kidney and diabetic diseases, asthma, chronic obstructive pulmonary disease, Alzheimer's dementia, cancers...
A theory based on the cellular danger response (CDR: cell danger response): the researchers describe here the 3 stages of this natural and universal cellular reaction to injury or stress. The purpose of this CDR process is to help protect the cell and initiate the healing process. But sometimes the CDR gets stuck. At the molecular level, the cellular balance is altered, preventing the completion of the healing cycle and permanently altering the cell's response. When this happens, the cells behave as if they are still injured or in danger even though the original cause of the injury has passed.
Removing the danger via a small randomized clinical trial:
conducted last year in 10 boys with autism, treated with a single dose of a century-old drug that inhibits adenosine triphosphate (ATP), a small molecule produced by mitochondria cellular and serving as an alert, the trial shows when abnormal ATP signaling is silenced, treated participants show a marked improvement in their communication and social behaviors. An unfortunate benefit that remains transient, depending on drug levels.
Why Metabolic Dysfunction Drives Chronic Disease:
Progression in the healing cycle is controlled by mitochondria (Visual above) known to produce energy for cell survival and metabokines, metabolic signaling molecules to regulate cell receptors including those related to healing. Abnormalities in metabokine signaling cause an abnormal persistence of the cellular response to danger, creating the famous blockage in the healing cycle.
From there comes the idea of targeting new treatments to these underlying processes and agents that block the healing cycle. These new treatments would only be administered over a short period of time, with the aim of restarting the natural cycle leading to a cure. Finally, this study and its prospects confirm the conclusions of previous studies: This is not the first time that it is considered to boost the mitochondria to repair cellular metabolism.
What cells are affected by autism?
Researchers compared the brain images of 77 people with autism spectrum disorder with those of 88 people without a developmental disorder and found that people with autism have fewer brain cells and axons, the long cables that connect brain cells.
What happens when cells are damaged?
Toxic damage to cells can cause individual cell death and if sufficient cells are lost, the result can be tissue or organ failure, ultimately leading to death of the organism. It is nearly impossible to separate a discussion of cellular toxicity and biochemical toxicity.
What are the different types of cellular abnormalities?
Atrophy, Hypertrophy, Hyperplasia, Metaplasia, and Dysplasia, are all cellular adaptations to the demands of function or the effects from environmental stimuli or damaging disease. All cells die--they are pre-programmed genetically to do this (what is called "apoptosis").
What affects cellular health?
Nutrition. Naturally, nutrition also plays a big role in cellular health. What you put into your body affects cells' ability to replicate properly and to make the bodily tissues you need in order to repair daily damage, build new muscle, and stave off the effects of aging, like the risk of osteoporosis.
What are cellular defects?
Cellular abnormality is the deviation or malformation from the typical phenomenon. There are situations when body cells show abnormality in cell multiplication and proliferation. This can be due to the mutation in the genes of the cell.
What are chronic diseases driven by metabolic dysfunction?
This biology is at the root of virtually every chronic illness known, including susceptibility to recurrent infections, autoimmune diseases like rheumatoid arthritis, diabetic heart and kidney disease, asthma, chronic obstructive pulmonary disease, Alzheimer's dementia, cancer and autism spectrum disorder.”
How do I turn off cell danger response?
Improving the health of the ecosystem in the gut reduces oxidative stress and inflammation. Eliminating the threat, turns off the CDR as does supporting the repair of cells and tissues with more resources via diet, methyl B12 injections, essential fatty acids and antioxidants like glutathione.
What is the cell danger response in autism?
Research in our lab has led us to the conclusion that the root cause of autism spectrum disorder (ASD) is a persistent cell danger response (CDR)1-7 that is maintained by abnormalities in ATP (purinergic) signaling. This can start with a mutant gene.
What causes cellular stress?
Stresses to cells and organisms originate from a variety of sources, including mechanical injury, pathogens, toxic compounds in the environment, naturally occurring agents that damage cells such as ultraviolet light, nutrient or oxygen deprivation, and many more.
What is the name of the process that can trigger cell damage?
Apoptosis is mediated by proteolytic enzymes called caspases, which trigger cell death by cleaving specific proteins in the cytoplasm and nucleus.
What are 2 causes of chronic diseases?
Most chronic diseases are caused by key risk behaviors: Tobacco use and exposure to secondhand smoke. Poor nutrition, including diets low in fruits and vegetables and high in sodium and saturated fats. Physical inactivity.
What are the big 4 chronic diseases?
The four chronic conditions are cardiovascular disease, cancer, chronic lower respiratory disease, and diabetes. These four conditions cause more than 50 percent of all deaths in that vast majority of communities.
What is the most common chronic disease?
Number 1: Hypertension (high blood pressure)
The danger of hypertension is not only that you can have it for years and not know it, but it can cause other serious health conditions, like stroke and heart attacks.
What are the 5 main chronic diseases?
Chronic diseases - such as heart disease, cancer, diabetes, stroke, and arthritis - are the leading causes of disability and death in New York State and throughout the United States.
What are the 3 major chronic diseases?
Image result for CHRONIC DISEASES: It all starts with a blockage of the cellular response to danger
Chronic diseases such as heart disease, cancer, and diabetes are the leading causes of death and disability in the United States. They are also leading drivers of the nation's $4.1 trillion in annual health care costs.
What triggers cell danger response?
The cell danger response (CDR) is an evolutionarily conserved cellular metabolic response that is activated when a cell encounters a chemical, physical, or microbial threat that could injure or kill the cell. Common microbial threats are viruses, bacteria, fungi, and parasites.
What is the cellular danger response?
Abstract. The cell danger response (CDR) is the evolutionarily conserved metabolic response that protects cells and hosts from harm. It is triggered by encounters with chemical, physical, or biological threats that exceed the cellular capacity for homeostasis.
