Insulin tablets under test.. Escape from the process of digestion and absorption into the circulation

Insulin tablets under test

Because insulin is a protein be Is broken down in the stomach so the new methods used to connect the insulin molecule with a chemical compound originally multiplier polymer In order to escape from the digestive process and is absorbed into the circulation. Initial studies demonstrated side effects do not appear and can address these disks quarter of an hour before eating.

Diagnosis

Your doctor is likely to start by reviewing your medical history and performing a careful physical examination. These assessments may be sufficient if your indigestion is mild and you don't have certain symptoms, such as weight loss and frequent vomiting.

But if your indigestion started suddenly and you're having severe symptoms or you're over 55, your doctor might recommend:

• Laboratory tests to check for anemia or other metabolic problems.

• Breath test and stool analysis to check for the presence of H. pylori, a bacteria associated with peptic ulcers that may cause indigestion.

• Endoscopy to check for abnormalities of the upper digestive tract, especially in older people with more persistent symptoms. A tissue sample (biopsy) may be taken for analysis.

• Imaging tests (X-rays or CT scans) to look for intestinal obstruction or any other problem.

treatment

Lifestyle changes can help relieve indigestion. The doctor may recommend:

• Avoid foods that trigger indigestion

• Eat five or six small meals a day instead of three large meals

• Reducing or completely eliminating alcoholic beverages or caffeine

• Avoiding certain pain relievers, such as aspirin, ibuprofen (Advil, Motrin IB, others), and naproxen sodium (Aleve)

• Find alternatives to medications that cause indigestion

• Control feelings of stress and anxiety

If your indigestion persists, you may find relief with medications. Over-the-counter antacids are generally the first choice. Other options include:

• Proton pump inhibitors, which can reduce stomach acid secretion. Proton pump inhibitors may be recommended especially if you have heartburn in addition to indigestion.

• H2 receptor blockers, which can also reduce stomach acid secretion.

• motility stimuli, which may be useful if gastric emptying is slow

• Antibiotics, which can be helpful if H. pylori is causing your indigestion.

• Antidepressant or anti-anxiety medications, which may reduce the discomfort of indigestion by reducing the sensation of pain.

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Giving insulin in the form of tablets for oral.. Cracking the hormone insulin and lack of effectiveness by digestive enzymes in the stomach

Giving insulin in the form of tablets for oral

There is no doubt that giving oral medication is the appropriate way and comfortable for patients.

And has been the experience of giving insulin in the form of tablets and oral solutions but that method is not effective because of the cracking of the hormone insulin and lack of effectiveness by digestive enzymes in the stomach.

And there are promising experiments are made ​​by a team of Chinese scientists in January 2007 on experimental animals, specifically rats updated sugar and giving insulin in the form of oral solution. The main method encapsulates the hormone insulin substance known as Kitusan Chitosan , A chemical extracted from seashell shrimp,

The crabs are made in the form of very small particles. And then put those small molecules in aqueous solution given by mouth in experimental animals. The results of the study showed that giving insulin in this way led to the intestinal absorption of insulin and bringing them to the blood well and led to a reduction in the level of sugar in the blood. Work is currently underway to see if insulin was given in this way in humans will lead to similar results are good.

Can insulin be taken in pill form?

The result is better glucose control, reduced hyper and hypoglycemia, and less weight gain. In addition, oral insulin is easier for diabetics to incorporate into their daily routine because they simply take a pill, removing the need for multiple daily injections and continual glucose measurements.

Why insulin Cannot be taken orally as a tablet and must be injected?

Insulin is a peptide hormone, therefore, destroyed by gastric acid if taken orally. Intradermal absorption of insulin is not reliable, and it cannot mimic physiological insulin secretion. In addition, intradermal, intramuscular and intravenous therapy is not suitable for self-administration daily.

What happens if you ingest insulin orally?

Despite poor bioavailability (1%) when taken orally, insulin may produce symptomatic hypoglycemia with a massive ingestion. Vigilant blood glucose monitoring, supportive care with glucose replacement therapy, and admission to the hospital for observation may be required.

Why can't insulin be administered as a tablet or capsule?

You take insulin as a shot. You can't take it like a pill because normal digestion would destroy it. There are several different types, and they all work in different ways.

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