Showing posts with label cultivation pancreas. Show all posts
Showing posts with label cultivation pancreas. Show all posts

Types of agriculture pancreas: Cultivation of the pancreas with the kidneys. Only cultivation pancreas

Types of agriculture pancreas:

There are two main types of agriculture pancreas:
  • Xenotransplantation: This is the process of transplanting a pancreas from another species, such as a pig, into a human.
  • Autotransplantation: This is the process of transplanting a pancreas from a living donor, such as a relative or friend, into a recipient.

Cultivation of the pancreas with the kidneys:

In some cases, the pancreas may be transplanted with the kidneys. This is known as a simultaneous pancreas-kidney (SPK) transplant. SPK transplants are typically performed on people with type 1 diabetes and kidney failure.

Only cultivation pancreas:

In other cases, only the pancreas may be transplanted. This is known as a pancreas-only transplant. Pancreas-only transplants are typically performed on people with type 1 diabetes who do not have kidney failure.

Benefits of pancreas transplantation:

Pancreas transplantation can be a life-saving procedure for people with type 1 diabetes. It can also help to improve the quality of life for people with type 1 diabetes by reducing the need for insulin injections and blood sugar monitoring.

Risks of pancreas transplantation:

Pancreas transplantation is a major surgery and carries some risks, including:
  • Rejection: The body may reject the transplanted pancreas.
  • Infection: The transplanted pancreas may become infected.
  • Bleeding: The transplanted pancreas may bleed.
  • Blood clots: Blood clots may form in the blood vessels that supply blood to the transplanted pancreas.

Side effects from medications:

The medications used to prevent rejection can have side effects, such as kidney damage, high blood pressure, and diabetes.

Overall, pancreas transplantation is a safe and effective procedure for most people with type 1 diabetes. However, it is important to weigh the risks and benefits of pancreas transplantation before making a decision about whether or not to have the surgery.

Success rate cultivation of beta cells in the pancreas of diabetic.. Increase the number of transplanted cells and giving immunosuppressive drugs

Success rate was growing beta cells initially very few. And improved results for the foreseeable future is by increasing the number of transplanted cells and giving immunosuppressive drugs. But the rate of level-term success is still disappointing.
In a study published in 2006 on 36 patients has them grow beta cells, showed that more than 40% of these patients stopped giving insulin them fully within one year of an agriculture operation. Within two years were off insulin completely for fewer than 14% of patients who were farming.

What happens after the cultivation of the beta cells in the pancreas of a diabetic? .. Need new cells cultivated to the point in time in order to work

Need new cells cultivated to the point in time in order to work. And requires the medical team monitoring his blood sugar level after the operation and give insulin when needed. If the process is successful agriculture, the amount of insulin is reduced gradually after new cells take their role in insulin secretion.

Pancreas transplants for patients with diabetes.. Continuous rise of sugar in the blood and can not control it in any kind of therapy

The pancreas transplants since 1960, and most of these operations has been associated with a kidney transplant. 
Kidney failure is one of the most important complications that occur when a diabetic, and a pancreas transplant may help to keep the overall semi-intact. 
In some successful kidney transplant operations in people with diabetes, you may not need to use insulin, but the success of these types of operations is not guaranteed dramatically. 
The human body may reject the new member after days or after years of cultivation. That means you'll need taking drugs to suppress the body's immune for life.
And these drugs have very serious side effects, so it should not pancreas transplantation except in the case of complications too large due to the continuous rise of sugar in the blood and can not control it in any kind of treatment.

What if I failed transplant beta cells in the pancreas of a diabetic? Re-treatment with insulin

At present there is no guarantee that the cell culture process will be successful. The rejects the body's immune system that cells cultivated exotic, as well as the new cells may not live in the liver, or the resumption of complications of diabetes may lead to the destruction of those cells. In the case of the death of these cells, the patient needs to re-treatment with insulin.

Complications that may occur after a pancreas transplant for a diabetic.. Bleeding. Mouth ulcer. Swelling of the foot.

Of the most important complications that may occur after the surgery and the use of immunosuppressive drugs:
** Body's rejection of the pancreas transferee. The process of rejection of the biggest obstacles facing transfers and organ transplantation in general. This is due to the immune system in the human body programmer not only   To destroy bacteria and viruses, but also tissue and transmitted regarded by foreign objects. And therefore must use immunosuppressive drugs to make movable members work well.
** Blood clot.
** Bleeding.
** Mouth ulcer.
* Nausea.
** Headaches.
* Swelling of the foot.
* Lack of white blood cells, which makes the patient vulnerable to infection.
** Hypertension.
** Increase blood fats (cholesterol and Turaagelesraad).
* Rotate the face.
** Stomach problems.
* The possibility of weight gain.
** Acne and facial hair.
Some of these side effects may be severe in the beginning but the severity may be reduced later.

Operation for the cultivation of the pancreas for diabetics.. Failure to remove the patient's pancreas, which continues to be done to make some other functions

The full pancreas transplant large and you need to work an opening in the abdomen and fully anesthetized patient is usually not the patient's pancreas is removed and which continues to work for some other functions.
It takes time kidney transplants with pancreatic together within 5-7 hours, and cultivation of the pancreas after previous cultivation of the kidneys, as well as the cultivation of the pancreas alone in the range of 2-4 hours. And must work the new pancreas in the case.
The patient will suffer from swelling and pain around the surgical opening. And the duration of the patient in the hospital after the operation, about 1-3 weeks, depending on the patient's health and the new pancreas.

What if new pancreas fails when diabetic?.. Use of insulin therapy and in re-thinking the farming process again

Could fail new pancreas either because the body has refused or for other reasons. When this happens, the patient can resume use of insulin therapy and in re-thinking the farming process again. This depends on the patient's health at the time of the scientific, and the patient's ability to endure the operation.

Wait for donors pancreas for diabetics.. Cultivation of beta cells by extracting the cells from the pancreas of a person volunteers and injected into the patient sugar

Found in the United States of America alone that nearly 2,500 people in any day of the year waiting for the cultivation of the pancreas with kidney, and that there are nearly 1,700 people waiting for pancreas transplant alone. However not available from donors only 900 people a year for the cultivation of the pancreas with the kidneys, and about 500-600 people a year for the cultivation of the pancreas alone.
Due to the difficulty of obtaining a full member of the deceased persons because of the desire of some to donate their organs after death, and to reduce the waiting period for diabetics and may result in serious complications may lead his life, there experiments are underway to cultivate part of the pancreas instead of the full User is taken of living persons. Was conducted only about 50 operations this way.
Most of these operations were performed on patients who underwent kidney transplantation with pancreas at the same time, where I give these patients one kidney and part of the pancreas of a person volunteer neighborhood. Well is currently testing beta cell transplants by extracting the cells from the pancreas of a person volunteers and injected into the patient sugar.

Cultivation of beta cells of the pancreas for diabetics.. Avoid obstacles donate whole pancreas

This method is a new alternative for the cultivation of the pancreas in order to avoid obstacles to donate the whole pancreas. This type of farming is still on probation and not as effective as the cultivation of the pancreas, at least at the present time. The aim of this process   To give a diabetic new cells capable of producing insulin. This is done by extracting the cells from the pancreas of a person volunteers instead of planting a full member.
Unlike the process of agriculture full of the pancreas, the cultivation of beta cells does not require a major operation and the patient requires local anesthesia only and does not require staying in the hospital or be short and therefore this method may be a good alternative for growing entire pancreas, if successful, for patients with type I diabetes.
This method is injected beta cells through a thin needle in the umbilical vein (Umbilical vein ) In the abdomen of the person receiving or made ​​an opening in the abdomen through which pass a tube to the hepatic vein (Portal vein) And those cells are injected through the tube. The liver is a good place to grow beta cells for easy access more of the pancreas as those transplanted cells produce insulin better presence in the vicinity of the liver.
And include the cultivation of beta cells to take cells from the same patient sugar This method is calledIslet cell autotransplantation   Or that those cells are taken from someone else and called Islet cell allotransplantation And beta cells can be used from the same patient sometimes sugar to prevent the development of diabetes and when it requires the removal of the pancreas - for example, in the case of patients who suffer from chronic inflammation of the pancreas accompanied by pain is difficult to treat.The process of transfer of the beta cells of another person, for the treatment of people who suffer from diabetes, which is difficult to control and has not yet reached the stage of serious complications associated with diabetes.
To perform this operation it would require to the need for a number two or more of the pancreas from the volunteer to get a sufficient number of beta cells sufficient for agriculture for a single patient only).

Altovat new pancreas in a patient with diabetes.. The possibility of healing after pancreas transplantation is very good

The possibility of healing after pancreas transplantation is considered very good. Most patients who are growing pancreatic enjoy the good life. The average life of the pancreas Moved in patients who have kidney transplants with pancreas at the same time in the range of 86% during the first year, and 77% within three years, and 70% within five years. The average life of the pancreas in patients who are planting the pancreas only the equivalent of 81% in the first year, and about 65% within three years, and 52% within five years. The statistics showed that the cultivation of the pancreas with kidney at the same time give a better rate for the life of both members after five years of agriculture.

Patients who are eligible for a pancreas transplant.. Diabetics who are dependent on insulin and who do not respond well to treatment with insulin

Is a pancreas transplant in diabetics who are dependent on insulin and who do not respond well to treatment with insulin at the same time to have serious complications due to control the level of sugar in the blood. In the majority of diabetics use insulin may be a lifetime best at least at the present time and this because of the need for patients to take immunosuppressive drugs (Immunosuppressives ) After a pancreas transplant to prevent the body's rejection of the pancreas transferee. The patient may have to take some of these medications for life. These drugs are toxic and may cause serious harm to the patient's body. Therefore, a pancreas transplant may be appropriate for patients who are taking these drugs originally for other reasons - for example, in persons who has kidney transplant because of kidney failure.

Intended to grow pancreatic.. Cultivation of healthy pancreas unable to produce insulin in a person with diabetes

Is a healthy pancreas transplant is able to produce insulin in a person with diabetes. And get the whole pancreas of newly deceased person or by donating a portion of it from a survivor. The person can donate half of the pancreas at the same time live a normal life. And persons who are agriculture are infected with type I diabetes, and in general be age within 55 years or less. And 95% of cases of pancreas are growing in patients with kidney disease due to diabetes, or patients who have already been to them a kidney transplant in the past and continues to operate successfully.

Agriculture pancreas.. Development and use of the hormone insulin as a successful drug to avoid secondary complications associated with the sugar

In the beginning of the century, the average survival of diabetics alive within just two years of the beginning of the first diagnosed with type of sugar. The development and use of the hormone insulin as a successful drug to make a great revolution in the treatment of patients with diabetes and convert it from a disease rapidly lead to death to a chronic disease. Regrettably, lengthening the age of diabetics with the survival of the disease has led to the emergence of secondary complications associated with the sugar, which include kidney failure, neuropathy and retina, and other complications on small and large arteries.These complications occur after 10 - 20 years of the onset of diabetes.
Many of the patients with type I diabetes is controlled by the level of sugar they have through sport, nutrition and insulin injections.
But some patients find it difficult to control the level of sugar they use these roads and result in serious complications in the short term and long term. Cultivation of the pancreas may be successful alternative for patients with type I advanced diabetes who do not respond well to treatment with insulin and who show serious complications due to the disease. The aim pancreas transplant to improve the first type of diabetes and not to rely on insulin. 
The first pancreas were planted in the world in 1966 by Dr. Richard Aleahy (Richard lillehei ) From the University of Minnesota in the United States of America, where the pancreas were planted with kidney at the same time successfully. Then followed by agriculture with kidney and pancreas twelve sick at the age of 28 years. Despite the low level of sugar in the blood immediately after the transplant but died three months later due to lung problems. In 1979 was the first part of the growing pancreatic people volunteers neighborhoods. Those operations were considered in the experimental stage until the year 1990. At present, the cultivation of the pancreas are therapeutically acceptable. In the United States there are currently approximately 100 medical center for the cultivation of the pancreas is approximately 1,400 state grow pancreas annually. This number is very limited due to lack of members that are donated by deceased persons for the purpose of agriculture.
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