Pathological picture of mad cow disease.. Spongy voids within the stoplase of neurons on both sides of the brain and neutral cells of the brain membranes The histological examination detects a lesion in the brain, which is a spongy cavity within the stoplasm of neurons on both sides of the brain and the neutral cells of the brain's membranes. Share This: Facebook Twitter Google+ Stumble Digg Email ThisBlogThis!Share to XShare to Facebook