Cyclophosphamide requires activation of the liver; therefore it can be given orally and is not dilated if given intravenously. Like all drugs, its major toxic effects are suppression of bone marrow, alopecia, nausea and vomiting. It can also cause hemorrhagic inflammation in the bladder; increased fluid intake for 24-48 hours will help avoid this doubling.
Cyclosophosphamide is used either as part of the treatment or as an adjunct to non-Hodgkin's lymphoma, breast cancer, childhood leukemia and ovarian cancer. It is also used in many palliative treatment regimens.
Cyclosophosphamide is used either as part of the treatment or as an adjunct to non-Hodgkin's lymphoma, breast cancer, childhood leukemia and ovarian cancer. It is also used in many palliative treatment regimens.
