Azathioprine is the most widely used drug in transplant recipients.
It is useful when corticosteroid therapy alone has been shown to be inadequate or for other cases when corticosteroid dose reduction is required. It is metabolized to mercaptopurine and as with mercaptopurine doses should be reduced when given with alopurinol.
The predominant toxic effect is pure suppression, although hepatotoxicity also occurs.
It is useful when corticosteroid therapy alone has been shown to be inadequate or for other cases when corticosteroid dose reduction is required. It is metabolized to mercaptopurine and as with mercaptopurine doses should be reduced when given with alopurinol.
The predominant toxic effect is pure suppression, although hepatotoxicity also occurs.