Hemoglobin breakdown takes place in.. RES



**Perl's stain
- BM iron stores

** Hemoglobin breakdown takes place in:
a. RES
b. Hepatocytes.
c. Renal tubules.

a. Normally 6gm of Hb is broken down per day into;
- Globin peptides: hydrolysed and the amino acids enter into the body amino acid pool.
- Iron:  reutilized.
- Porphyrin ring: broken down in the reticuloendothelial cells of the liver, spleen and bone marrow to bile pigments.