How do ACE inhibitors affect the bradykinin system?
a. Increase degradation of bradykinin
b. Decrease degradation of bradykinin
c. Increase production of bradykinin
d. Increase kallikrein production
Answer b:
Degradation of bradykinin relies on ACE. Inhibition with ACE inhibitor allows build-up of bradykinin, which likely mediates the “cough” found in some patients intolerant of ACE inhibitor.
a. Increase degradation of bradykinin
b. Decrease degradation of bradykinin
c. Increase production of bradykinin
d. Increase kallikrein production
Answer b:
Degradation of bradykinin relies on ACE. Inhibition with ACE inhibitor allows build-up of bradykinin, which likely mediates the “cough” found in some patients intolerant of ACE inhibitor.
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Radiology