Drug family: Antiandrogen
This drug is a generic of ANDROCUR
IN WHICH CASE IS THE DRUG CYPROTERONE ACETATE EG PRESCRIBED?
This medicine contains a derivative of progesterone . It has an antihormonal action: it opposes the action of androgen hormones , essentially testosterone . In men, its action slows down the growth of prostate cells . In women, androgen hormones are present in small quantities and are involved in hair disorders and excess sebum.
prostate cancer ; _ _
hirsutism in women, when excessive hair has a serious effect on emotional and social life (50 mg tablet);
certain forms of paraphilia, in association with psychotherapeutic treatment (100 mg tablet).
You can consult the following article(s):
- Prostate cancer
PRESENTATIONS OF THE DRUG CYPROTERONE ACETATE EG
The prices mentioned do not take into account the pharmacist's " dispensing fees ".
COMPOSITION OF THE DRUG CYPROTERONE ACETATE EG
| p cp | p cp | |
| Cyproterone acetate | 50mg | 100mg |
| Lactose | + | + |
CONTRAINDICATIONS OF THE DRUG CYPROTERONE ACETATE EG
severe liver disease, certain rare diseases causing excess bilirubin in the blood;
tuberculosis or deterioration in general condition linked to a serious illness;
thromboembolic accident ( phlebitis , pulmonary embolism, myocardial infarction , etc.) old or occurring during treatment;
severe depression ;
sickle cell anemia ;
presence of an old or recent meningioma ( brain tumor );
history of herpes gestationis, jaundice or prolonged itching during pregnancy (50 mg tablet).
ATTENTION
This medication can, in high doses, be responsible for sometimes serious liver damage. A liver test is usually ordered before starting treatment. Immediately report to your doctor any symptom that could lead to fear of a toxic effect on the liver: persistent abdominal pain, loss of appetite, dark urine, intense itching, jaundice. Analyzes may be necessary to ensure the absence of anomaly.
Medical monitoring should be reinforced in the event of diabetes or chronic liver disease.
When used in women, gynecological monitoring (breasts, uterus) is recommended.
Thromboembolic accidents have been reported during treatment: in the event of the occurrence of significant and unusual headaches, visual disturbances or increased blood pressure , seek prompt medical advice.
Studies have shown a marked increase in the risk of occurrence of meningioma ( most often benign brain tumour ) in patients treated with cyproterone acetate at high doses over a long period. The duration of treatment should be as short as possible and the dose used as low as possible. A search for meningioma by brain imaging ( MRI ) must be carried out at the start of treatment, then regularly if the treatment is continued for several years. If a meningioma is diagnosed, treatment should be permanently discontinued. An information sheet will be given to you by the doctor at the time of the prescription.
If you must drive or use a dangerous machine, make sure beforehand that this medicine does not affect your alertness .
INTERACTIONS OF THE DRUG CYPROTERONE ACETATE EG WITH OTHER SUBSTANCES
herbal products containing St. John's wort and medicines containing perampanel,
emergency contraceptives containing ulipristal ( ELLAONE ...).
Also tell your doctor or pharmacist if you are taking a medicine containing any of the following substances: carbamazepine, fosphenytoin, phenobarbital, phenytoin, primidone, oxcarbazepine, rifabutin, rifampicin, nevirapine, efavirenz, dabrafenib and enzalutamide.
FERTILITY, PREGNANCY AND LACTATION
PREGNANCY :
This drug has no indication in pregnant women. It is necessary to ensure the absence of pregnancy before starting treatment.
Cyproterone acetate blocks ovulation and has a contraceptive effect .
In the event of temporary discontinuation of treatment (for example in the event of forgetting the signed certificate authorizing the delivery of the medicinal product), another effective contraceptive method must be used in women of childbearing age.
FEEDING WITH MILK :
The available data do not allow to know if this medicine passes into breast milk; a choice is therefore necessary between breastfeeding and taking the drug. This decision should be made in consultation with your doctor.
INSTRUCTIONS FOR USE AND DOSAGE OF THE DRUG CYPROTERONE ACETATE EG
This medication should be swallowed with a glass of water.
USUAL DOSE:
Prostate cancer : 4 to 6 tablets at 50 mg per day or 2 to 3 tablets at 100 mg per day, in 2 or 3 doses.
Hirsutism :
Premenopausal woman : 1 tablet at 50 mg per day for 20 days per month, in combination with an estrogen , followed by a 7-day break. As maintenance therapy , depending on clinical signs, the dose may be reduced to 1/2 50 mg tablet daily for 20 days per month, in combination with an estrogen , followed by a 7-day break
Postmenopausal woman : 1/2 or 1 50 mg tablet per day, if possible in combination with an estrogen .
Reduction of sexual urges: the dosage is individual.
TIPS
In premenopausal women, additional local contraception is necessary during the first 2 cycles. If you forget a tablet, take the tablet as soon as you remember. If the delay in taking exceeds 12 hours, contraceptive security is no longer assured. An additional contraceptive method (condoms) must be used until the onset of menstruation. In the absence of periods during the 7 days without treatment, a pregnancy test must be performed to verify the absence of pregnancy before resuming treatment.
Specific delivery conditions :
To obtain this medicine, an information certificate on the risk of meningioma, signed by the patient and his doctor, must be presented to the pharmacist at the same time as the prescription. This certificate is valid for one year, and must therefore be renewed each year if the treatment is continued.
POSSIBLE SIDE EFFECTS OF THE DRUG CYPROTERONE ACETATE EG
decrease in sperm production usually reversible on discontinuation of treatment, which may lead to temporary sterility;
gynecomastia , impotence , low libido, sweating, hot flushes, anemia ;
bone loss in case of prolonged treatment.
In women: breast tension, change in libido, menstrual disorders (slight bleeding between periods, cessation of periods, etc.).
In women as in men: weight change, shortness of breath, heavy legs, migraine , headaches, rash , fatigue, restlessness and depression .
Rarely: hepatitis , thromboembolic accident, meningioma (which may result in various symptoms such as frequent headaches, vision, language, memory and hearing disorders, nausea, dizziness , convulsions , loss of smell , weakness, paralysis ).
