The alternative agent is the center of the extract agent of the plasma, these frozen concentrates are dried and contain a large amount of coagulation factor. But the new factor concentrates have eliminated the risk of viral contamination. The research offers one step forward to create non-derivative products of blood or plasma. Some of the products of Factor VIII are manufactured by gene research technology and eliminated the spread of viruses from the human body donated to the patient. This agent can immediately increase the level of clotting in the patient's blood and continue for 8-12 hours after taking the worker's needle. This factor can be taken when feeling the need for it, but it is advisable to take it every day after another to prevent any bleeding when the agent is available. Because of the high costs of this basic treatment, it is not always available in Palestine or is ever present in developing countries.