Laboratory and Biology Tests - In Vitro-In Vivo Correlations
The relationship between vitro-in vitro and bioavailability in in vivo is of interest at present. The US Food and Drug Administration (FDA) led the research program to test the relationship between the goals in order to gain a better knowledge of their mutual relationships and to use relationships as a means of predicting the form of achievement in the biology of information in the laboratory. The realization of the second objective will save costs significantly. It will be important to know the savings of achieving this second goal. This research in this region has been built on the differences between drugs or preparations in terms of solubility and membrane permeability.
Drugs or preparations can be classified into four groups:
1 - high solubility and low permeability.
2 - high solubility and high permeability.
3 - low solubility and high permeability.
4- Low solubility and low permeability.
The drugs in the third group will be the solubility determined for the absorption velocity and the melting information in the laboratory will be useful. On the other hand, in the first group drugs the permeability will be the most likely step and the laboratory data will be less useful.
For the second and fourth groups, the picture is less clear and the relationship between tests on biology - in vitro is necessary for experimental identification.
The relationship between vitro-in vitro and bioavailability in in vivo is of interest at present. The US Food and Drug Administration (FDA) led the research program to test the relationship between the goals in order to gain a better knowledge of their mutual relationships and to use relationships as a means of predicting the form of achievement in the biology of information in the laboratory. The realization of the second objective will save costs significantly. It will be important to know the savings of achieving this second goal. This research in this region has been built on the differences between drugs or preparations in terms of solubility and membrane permeability.
Drugs or preparations can be classified into four groups:
1 - high solubility and low permeability.
2 - high solubility and high permeability.
3 - low solubility and high permeability.
4- Low solubility and low permeability.
The drugs in the third group will be the solubility determined for the absorption velocity and the melting information in the laboratory will be useful. On the other hand, in the first group drugs the permeability will be the most likely step and the laboratory data will be less useful.
For the second and fourth groups, the picture is less clear and the relationship between tests on biology - in vitro is necessary for experimental identification.