Injections within the spinal cord fluid directly guarantee full bioavailability within the central nervous system of drugs that can cross the blood-brain barrier. These dosage methods are used to treat serious neurological infections in the central nervous system such as meningitis and ventricular inflammation and are used with spinal anesthesia agents such as mebivacaine and bilocarpine. The drugs injected into the flock are initially spread in about 140 ml of cerebrospinal fluid, so this method gives high concentrations within the central nervous system with less systemic toxicity risk.
