Medium-chain fatty acids and glycerides:
Increased interest in the use of glycerides and low-fat fatty acids as absorbers for absorption due to their presence in food products. The ability of some glycerides and fatty acids to increase the absorption of the drug under different conditions. And almost always in animals and in most cases after rectal administration. However, some studies have yielded positive results after the oral dose. The bioavailability of oral insulin has increased to 9-13% in relation to intramuscular injection with a combination of sodium dodecanoate and cytolytic alcohol. The uptake of Aftiraxone was enhanced by glycerol-1 mono-carbon after oral administration and by intravenous and rectal animals.
Although these classes of compounds can be used as absorption enhancers, they have a negative effect on the integrity of the mucosa. Where we need further research to assess risks and benefits.
Increased interest in the use of glycerides and low-fat fatty acids as absorbers for absorption due to their presence in food products. The ability of some glycerides and fatty acids to increase the absorption of the drug under different conditions. And almost always in animals and in most cases after rectal administration. However, some studies have yielded positive results after the oral dose. The bioavailability of oral insulin has increased to 9-13% in relation to intramuscular injection with a combination of sodium dodecanoate and cytolytic alcohol. The uptake of Aftiraxone was enhanced by glycerol-1 mono-carbon after oral administration and by intravenous and rectal animals.
Although these classes of compounds can be used as absorption enhancers, they have a negative effect on the integrity of the mucosa. Where we need further research to assess risks and benefits.