HBA1c (Glycosylated hemoglobin) is?
a. Not present in healthy normal individuals.
b. ↑ in prolonged sustained hyperglycemia
(b) GlycHb (RR 4-6%) is formed by non enzymatic attachment of glucose to N-terminal valine of B-chain of Hb. Three types occur, HbA1a, HbA1b, HbA1c, Both total and HbA1a are used.
Time averaged blood glucose = GlycHbx33.3-86 (mg/dL)
GlycHb reflects 8-12 weeks of blood glucose while fructosamine reflects 2-4 weeks.
a. Not present in healthy normal individuals.
b. ↑ in prolonged sustained hyperglycemia
(b) GlycHb (RR 4-6%) is formed by non enzymatic attachment of glucose to N-terminal valine of B-chain of Hb. Three types occur, HbA1a, HbA1b, HbA1c, Both total and HbA1a are used.
Time averaged blood glucose = GlycHbx33.3-86 (mg/dL)
GlycHb reflects 8-12 weeks of blood glucose while fructosamine reflects 2-4 weeks.