H+ homeostasis is altered by;
a. Excessive change of pyruvate to lactate.
In actively contracting muscle, 8% of the pyruvate is utilised by the citric acid cycle and the remaining molecules are reduced to latctate. This lactate is oxidized by the liver to pyruvate which ,through gluconeogenesis, becomes glucose. If lactate is not efficiently reutilized in such a way, it accumulates in the blood causing lactic acidosis.
a. Excessive change of pyruvate to lactate.
In actively contracting muscle, 8% of the pyruvate is utilised by the citric acid cycle and the remaining molecules are reduced to latctate. This lactate is oxidized by the liver to pyruvate which ,through gluconeogenesis, becomes glucose. If lactate is not efficiently reutilized in such a way, it accumulates in the blood causing lactic acidosis.