Phenylketonuria is caused by the lack of an enzyme to metabolize.. Phenylalanine Phenylketonuria is caused by the lack of an enzyme to metabolize: [A] Leucine [B] Tyrosine [C] Alanine [D] Phenylalanine [E] Histidine Answer [D] Share This: Facebook Twitter Google+ Stumble Digg Email ThisBlogThis!Share to XShare to Facebook