HomeOral medicine The organelle most closely associated with the manufacture of proteins within the cell.. Ribosome The organelle most closely associated with the manufacture of proteins within the cell: a. Ribosome. *** b. Lysosome. c. Nucleolus. d. Cell wall. e. Cell membrane. Facebook Twitter Share:The organelle most closely associated with the manufacture of proteins within the cell.. Ribosome Facebook Twitter WhatsApp Pinterest LinkedIn Reddit Tumblr Telegram Email