Melobroxidase deficiency.. Increased susceptibility to infections especially for double gram negatives such as nazeria. Autoimmune diseases



Melobroxidase deficiency:
It is relatively common and inherited as an autosomal recessive. Melobroxidase is a component of neutrophil-loving neutrophil granules. The production of oxalide and other toxic media is important for the cytotoxic function, the topical meloproxidase gene on the chromosome 17.
Clinical manifestations:
- Disturbance of killing neutrophils of bacteria and bacteria abroad.
- The percentage of bacterial infections does not increase.
- Deep Candida infections.
- The supplemental deficiency
- Supplementary deficiency C1 Astrase.
Clinical manifestations:
- Bacterial infections.
- Increased susceptibility to infections, especially for double-gram negatives such as nazeria.
- autoimmune diseases.
- The lack of early compounds through the classic activation of the supplement leads to different clinical manifestations depending on the pattern of incomplete complement.