The cause of the disease is not known exactly Unknown Aetiology, but there are factors that help to appear:
1. Hereditary hereditary factors:
The disease affects similar twins by 25% and is not similar by 3%, and the relatives of the patient have the risk of infection by 3%.
Genetic factors Genetic:
People with the disease have the following genetic pigments than others HLA-B8 and HLA-DR3.
3 - the case of sex hormones Sex Hormone Status:
The disease is most common in women about menopause, premenopausal women, where sex hormones begin to decline, and in males with Klinefelter's Syndrome.
Immunological Factors:
- Hyperactivity in the work of white blood cells (B cells) B cells and that produce antibodies auto-Antibodies against antigen antigens of the nucleus of cells.
Immune Complexes (which consist of antigen, antibodies, or antibodies to the body), or the body's inability to dispose of them, leading to their deposition in tissues such as blood vessels and kidneys that cause inflammation .
- A defect in the regulation of white blood cells (T cells) T cells to work the immune system.
- Overproduction of inflammatory media such as interleukin 1 and interleukin 2 (IL-1, IL-2).
Environmental factors Environmental Triggers:
Some medications such as Hydralazine, Procainamide, Methyldopa, Isoniazid, Isoniazid, Minocycline, D-Penicillamine, can cause lupus erythematosus. The pills and hormones used in menopause increase the severity of the disease and ultra violet also shows the disease.
Viruses as a cause of disease, by causing the production of antibodies to the components of the cell nucleus.
1. Hereditary hereditary factors:
The disease affects similar twins by 25% and is not similar by 3%, and the relatives of the patient have the risk of infection by 3%.
Genetic factors Genetic:
People with the disease have the following genetic pigments than others HLA-B8 and HLA-DR3.
3 - the case of sex hormones Sex Hormone Status:
The disease is most common in women about menopause, premenopausal women, where sex hormones begin to decline, and in males with Klinefelter's Syndrome.
Immunological Factors:
- Hyperactivity in the work of white blood cells (B cells) B cells and that produce antibodies auto-Antibodies against antigen antigens of the nucleus of cells.
Immune Complexes (which consist of antigen, antibodies, or antibodies to the body), or the body's inability to dispose of them, leading to their deposition in tissues such as blood vessels and kidneys that cause inflammation .
- A defect in the regulation of white blood cells (T cells) T cells to work the immune system.
- Overproduction of inflammatory media such as interleukin 1 and interleukin 2 (IL-1, IL-2).
Environmental factors Environmental Triggers:
Some medications such as Hydralazine, Procainamide, Methyldopa, Isoniazid, Isoniazid, Minocycline, D-Penicillamine, can cause lupus erythematosus. The pills and hormones used in menopause increase the severity of the disease and ultra violet also shows the disease.
Viruses as a cause of disease, by causing the production of antibodies to the components of the cell nucleus.