Medicinal methods of medicine .. Avoid high absorption of the drug in the visceral circulation and the possibility of metabolism in the first hepatic passage

The methods of delivery of the injectable medicine are those methods that do not lead to a high absorption of the drug in the splanchnic circulation, and thus avoid the possibility of metabolism of the first hepatic passage. It should be noted that some injections do not avoid the effects of other first-generation metabolism (eg pleural metabolism of some inhalatory drugs).
Some of the main methods of administering the drug include the arterial pathway, intrathecal, intravenous, transdermal, nasal, buccal, intraperitoneal, vaginal and rectal.