consider patient tolerance to nitrate:
a- isosorbide dinitrate less tendency to make tolerance
b- tolerance affected by drug intake schedule***
c- tolerance not affected by drug intake schedule
nitrates depletes sulfhydral gps so tolerance occure so must there nitrate free period every day.
a- isosorbide dinitrate less tendency to make tolerance
b- tolerance affected by drug intake schedule***
c- tolerance not affected by drug intake schedule
nitrates depletes sulfhydral gps so tolerance occure so must there nitrate free period every day.
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pharmac