Which one of the following is not a recognised treatment in primary pulmonary hypertension.. Endothelin-1 receptor agonists

Which one of the following is not a recognised treatment in primary pulmonary hypertension?
A.A Endothelin-1 receptor agonists***
B.A Heart-lung transplant
C.A IV prostaglandins
D.A Diuretics
E.A Calcium channel blockers.
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