Homepharmacology Which of the following drug will antagonize Methotrexate.. Cyanocobalamin Which of the following drug will antagonize Methotrexate? a- Thiamine b- Folic acid c- Biotin d- Cyanocobalamin. Facebook Twitter Share:Which of the following drug will antagonize Methotrexate.. Cyanocobalamin Facebook Twitter WhatsApp Pinterest LinkedIn Reddit Tumblr Telegram Email