Chemical Mediators:
These include histamine, bradycin, serotonin, prostaglandins, PAF and ECF in the anaphylaxis and can be classified into two groups:
Pre-fabricated chemical media such as histamine, serotonin, heparin, chemical attractants of urea, modulators and proteases produced by cells and stored in granules. These substances are manufactured and stored in granules in mast cells, which are released directly and are responsible for the early phase occurring within minutes.
- Newly synthesized chemical media such as prostaglandins, leukotrienes, trombocene and PAF. These media are produced when exposed to the sensor and take several hours to be manufactured and cause symptoms during the late phase.
This media causes an interaction that occurs in two phases:
1 - rapid response early (early stage): within 5-30 minutes of exposure to the sensor and occurs in the expansion (expansion of capillaries and sharks) and increase the permeability of the capillaries and edema, as well as smooth muscle contractions and increase mucous secretion, this phase is affected by the treatment of antihistamines.
Late response: After several hours of exposure, 50% of the patients are under the influence of the newly formed media, especially leukotrien. Th2 thrombocytopenia, monoclonal, acidic, systemic and PMNs occur. , Which is responsible for inflammatory response and tissue damage, this phase is not affected by anti-histamine treatment and is affected by corticosteroids.
These include histamine, bradycin, serotonin, prostaglandins, PAF and ECF in the anaphylaxis and can be classified into two groups:
Pre-fabricated chemical media such as histamine, serotonin, heparin, chemical attractants of urea, modulators and proteases produced by cells and stored in granules. These substances are manufactured and stored in granules in mast cells, which are released directly and are responsible for the early phase occurring within minutes.
- Newly synthesized chemical media such as prostaglandins, leukotrienes, trombocene and PAF. These media are produced when exposed to the sensor and take several hours to be manufactured and cause symptoms during the late phase.
This media causes an interaction that occurs in two phases:
1 - rapid response early (early stage): within 5-30 minutes of exposure to the sensor and occurs in the expansion (expansion of capillaries and sharks) and increase the permeability of the capillaries and edema, as well as smooth muscle contractions and increase mucous secretion, this phase is affected by the treatment of antihistamines.
Late response: After several hours of exposure, 50% of the patients are under the influence of the newly formed media, especially leukotrien. Th2 thrombocytopenia, monoclonal, acidic, systemic and PMNs occur. , Which is responsible for inflammatory response and tissue damage, this phase is not affected by anti-histamine treatment and is affected by corticosteroids.
Labels
Food allergy