Progesterone maintains the integrity of the pregnancy - Ladin’s sign, an early indication of pregnancy - the abdominal line from the symphysis pubis to the umbilicus

- Progesterone maintains the integrity of the pregnancy by inhibiting uterine motility.

- Ladin’s sign, an early indication of pregnancy, causes softening of a spot on the anterior portion of the uterus, just above the uterocervical juncture.

- During pregnancy, the abdominal line from the symphysis pubis to the umbilicus changes from linea alba to linea nigra.