If a central nervous system (cns) drug is extensively ionized at the ph of blood it will.. Penetrate the blood - brain barrier slowly

If a central nervous system (cns) drug is extensively ionized at the ph of blood it will:
a- Penetrate the blood - brain barrier slowly***
b- penetrate the blood - brain barrier rapidly
c- Not penetrate the blood - brain barrier
d- Be eliminated slowly
e- Not to be distributed to any tissue sites.