The role of leptin in both obesity and inflammatory reactions is increasingly understood. Dumond and colleagues measured the leptin content in synovial fluid and cartilage samples for patients with degenerative degeneration and measured its effect after injection into the hinge on rat cartilage. The presence of leptin in synovial fluid for patients with degeneration of the joints and its association with body mass mass was observed. High levels of cartilage and cones were noted, but there was little in cartilage cells isolated from normal cartilage. The amount of cartilage leptin increased in the most affected joints, with increased association with growth factors such as IGF-1 and TGF beta-1. Animal studies have shown that leptin has a devastating effect on cartilage cells and the synthesis of IGF-1 and TGF beta-1,
Which increased in both mRNA and protein levels. This study suggests that leptin may be regulated for cartilage function, which requires further investigation.
Otero and colleagues proved that leptin is important to enhance the effects of nitrogen oxides NO. These studies have shown the beneficial effect of leptin on the increase in the production of nitrogen oxide, which is associated with the increase in cell death and typical cartilaginous cells, while interleukin 1 produces metalloproteinase and increases other inflammatory reactions in the metanxic joint. All this with other observations led to the belief that leptin may be an important rate for the scaling of episodes associated with progressive degenerative arthritis.
Which increased in both mRNA and protein levels. This study suggests that leptin may be regulated for cartilage function, which requires further investigation.
Otero and colleagues proved that leptin is important to enhance the effects of nitrogen oxides NO. These studies have shown the beneficial effect of leptin on the increase in the production of nitrogen oxide, which is associated with the increase in cell death and typical cartilaginous cells, while interleukin 1 produces metalloproteinase and increases other inflammatory reactions in the metanxic joint. All this with other observations led to the belief that leptin may be an important rate for the scaling of episodes associated with progressive degenerative arthritis.
