Which alpha-blocker has the strongest association with floppy iris syndrome.. Tamsulosin

Which alpha-blocker has the strongest association with floppy iris syndrome?
A- Alfuzosin
B- Indoramin
C- Prazosin
D- Tamsulosin***
E- Doxasosin

Answer D:
Although described as a class effect, the incidence of floppy iris syndrome with tamsulosin is approx 85%-90%.

The iris represents the colored part of the eyes and is often stiff and solid. However, if the infection is present, the iris becomes flexible. If the person is infected with white water and requires cataract surgery, this syndrome is dangerous to the eyes and prevents him from This procedure is performed, where the muscles of the eyes become flexible.
Tesosolucin is often the cause of the syndrome. If the condition is not treated, it can develop and lead to loss of vision. If a person is in the process of cataract surgery, it is necessary to stop taking these drugs for a long period of time. It does not cause any damage when doing surgery.

Intraoperative flotation iris syndrome (IFIS) is one of the complications that may occur during the extraction of white water in some patients. This syndrome is characterized by the presence of soft iris, which evaporates in response to fluid currents within the normal eye. This flexible iris tends to shrink to the white water extraction area during surgery, and the pupil narrowes during the operation, despite procedures to prevent it.
Transmissive iris syndrome has been associated with tamosolucin (eg, fluomox), a drug widely prescribed for urinary symptoms associated with benign prostatic hyperplasia (BPH).
Tacholin is a drug that works on alpha receptors selectively and works to relax the bladder and smooth prostatic muscles.
As such, it relaxes the extended muscle of the iris by connecting the endothelial nerve endings.
Many substances bind to different alpha receptors, but tamsolucin has a stronger association than others.
A joint statement by the two ophthalmologists states that the other major class of drugs to treat benign prostatic hyperplasia of alpha-5-reducing enzyme inhibitors does not appear to cause progressive iris syndrome.
 5-ARIs include finasteride, a drug commonly used as a first-line treatment for benign prostatic hyperplasia and androgenic pumpkin, and is also associated with white water formation.
The severity of the condition is not associated with the duration of thamsolucin intake.
Previous Post Next Post

Contact Form