The specificity of antigenic determinants and miscarriages .. Vascular lesion and thrombocytopenia are inhibited by suppressing prostocycline, which acts as an extensor of blood vessels

The specificity of antigen determinants and abortion Epitop specificity
It is now clear that APA antibodies interact with phosphorus lipids, but there is considerable debate about the antigen determinants of Epitops, which these antibodies interact with.
The phosphorus molecules are a component of the cell membranes. The antibodies to these phosphorylases are related to many pathological conditions, which have the effect of further academic studies. APA antibodies have the potential to disrupt vascular endothelium and thrombocytopenia by inhibiting prostacycline which is Act as an Vasodilator vasodilator and overlap
With the activation of C protein (Harris et al., 1985a, b), which causes platelet adhesion and the relative elevation of thromboxan, which acts as a vasoconstrictor, causing a vascular event that results in, Hematopoietic uterine death or obstruction of the fetus, due to lack of oxygen or blood contained in it.
Some phosphorus lipid molecules, particularly phosphotidylserine (PS) and phosphotidyl ethanolamine (PE), have adhesion properties, allowing cellular fusion. The cytotrophoblast layer becomes a cellular syncytiotrophoblast or a syncytia that regulates the passage of nutrients Of the fetus (Chong et al., 1995).
Some studies have demonstrated that monoclonal antibodies against PS (and not against CL) have the potential to discourage the emergence of an extracellular matrix, as well as the inclusion of women who have been subjected to spontaneous abortion with a high proportion of APA-IgM antibodies associated with the cellular Against phosphorus lipids (Chong et al., 1995).
The potential for maternal antibodies to phosphorus lipid molecules increases by 10% with each miscarriage and such an effect is cumulative (Beer & Kwak, 1991).
It was found that the monoclonal antibodies against DNA react interactively with the CL and have the effect of LA, suggesting that DNA and phosphorus lipids have general antigen receptors that interact with APA and that the phosphodiester group found in both DNA and phosphorytes are antigenic determinants, 1). It was also found that removing the glyceride fraction of the CL molecule causes its antigen loss, suggesting that the part of the clayside is essential for the antibody association that may help guide the phosphodiester group
 For good association with ACA antagonists. This may explain why antibodies are not associated with other structures containing phosphodiester groups as DNA molecules (Smeenk et al., 1987; Harris et al., 1985b).
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