A report from the University Group Diabetes Program in 1970 showed an increase in the number of heart disease deaths in diabetics treated with tulipiotamide compared to those treated with insulin injections.
There is still a contradiction to this day about the validity of this conclusion because there are observations on the design of the study.
Thus, the relationship between the death of patients due to heart disease and sulfonylurea drugs has not been demonstrated by clear and strong evidence.
For this reason, sulfonylurea is still widely used to treat patients with type 2 diabetes. However, in 1984, the Food and Drug Administration (FDA) obliged manufacturers of sulfonylurea drugs to write a warning about the increased risk of death from heart disease as a result of their use.
There is still a contradiction to this day about the validity of this conclusion because there are observations on the design of the study.
Thus, the relationship between the death of patients due to heart disease and sulfonylurea drugs has not been demonstrated by clear and strong evidence.
For this reason, sulfonylurea is still widely used to treat patients with type 2 diabetes. However, in 1984, the Food and Drug Administration (FDA) obliged manufacturers of sulfonylurea drugs to write a warning about the increased risk of death from heart disease as a result of their use.
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SULFONYL UREA DRUGS