Antihypertensive drugs, anti-giardic and leishmaniacs. Metronidazole. Miglomin Antimonials. Amphotericin b. Bentamidine

Antipyretic and antirheumatic drugs:
- diloxanide
- metronidazole
Drugs acting on adrenoreceptors
- meglumine antimoniate
Supplementary list:
- amphotericin B, pentamidine.

Antipyretics are active ingredients used to fight against feverish conditions and certain acute inflammatory syndromes. Their main indication is the fight against hyperthermia of the feverish state.

Indication:
The treatment of fever can be based on two main criteria:
- tolerance, which is subjective;
- the value of the temperature, which is objective (generally from 38.5 ° C).
In adults, the goal of prescribing an antipyretic may be based on tolerance to treat discomfort; but it is better to stick to the temperature in the young child and the infant, especially the severe increase in temperature can be accompanied by:
- of hidrorrhea.
- an increase in the mix.
- vomiting.
can cause rapid dehydration if the temperature does not drop rapidly.
The preferred medications are paracetamol and ibuprofen. Simple measures are usually associated, such as hydration and undressing, depending on their tolerance.

Examples of antipyretics:
- paracetamol.
- class of nonsteroidal anti-inflammatory drugs:
+ acetylsalicylic acid (aspirin).
+ ibuprofen.
+ ketoprofen.
+ quinine.

The use of antipyretics dates back to ancient times. Thus the Egyptians successfully used the decoctions of willow leaves to fight fever and pain. Later, around 400 BC J. - C., Hippocrates, according to which "the nature is the doctor of the patients", recommends, with a view to relieve the pains of the delivery and to lower the fever, a tea of ​​leaves of willow. Following the Greeks, the Romans resorted to the same remedy (the Latin name of the willow is salix). This use continued empirically until the eighteenth century.

The antipyretics used at that time were preparations from either natural compounds of cinchona bark (from which quinine is derived) or salicylate contained in the bark of willow. The cinchona bark became scarce and expensive, and the need to find substitutes appeared. Harmon Northrop Morse synthesized as early as 1878 a substance called acetylaminophenol, without however attributing any medical property to it: it was only fifty years later that it was marketed as a medicine under the name of paracetamol. At that time, other products were used as a cure for pain and fever: in 1882, Hoechst commercialized the Kairin discovered by Otto Fisher; in 1897, aspirin is synthesized by Felix Hoffmann and is a great success. BASF does not develop its antipyretic Thallin, developed around 188. Acetanilide (1886) and phenacetin (1887) are also used before the serious side effects of their administration are noted, while the disadvantages of aspirin are starting to be known. Paracetamol then reappears and the first studies on the antipyretic and analgesic properties of paracetamol are conducted at the end of the nineteenth century.