the modified Duke criteria used in the diagnosis of infective endocarditis.. Indwelling central line

Which one of the following features is not part of the modified Duke criteria used in the diagnosis of infective endocarditis?
A.A Fever > 38ºC
B.A Positive molecular assays for specific gene targets
C.A Indwelling central line***
D.A Elevated CRP
E.A Janeway lesions.
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