A female client with a history of pheochromocytoma is admitted to the hospital in an acute hypertensive crisis. To reverse hypertensive crisis caused by pheochromocytoma, nurse Lyka expects to administer:
a- phentolamine (Regitine).
b- methyldopa (Aldomet).
c- mannitol (Osmitrol).
d- felodipine (Plendil).
Answer A.
Pheochromocytoma causes excessive production of epinephrine and norepinephrine, natural catecholamines that raise the blood pressure.
Phentolamine, an alpha-adrenergic blocking agent given by I.V. bolus or drip, antagonizes the body’s response to circulating epinephrine and norepinephrine, reducing blood pressure quickly and effectively.
Although methyldopa is an antihypertensive agent available in parenteral form, it isn’t effective in treating hypertensive emergencies.
Mannitol, a diuretic, isn’t used to treat hypertensive emergencies
Felodipine, an antihypertensive agent, is available only in extended-release tablets and therefore doesn’t reduce blood pressure quickly enough to correct hypertensive crisis.
Phentolamine, known since 1950, is a fast-acting, short-acting, high-potency alpha-1-blocking adrenergic with a half-life of 20 minutes. It has been marketed in France for a long time under the name of Régitine but has not been used for many years. it remains marketed under the name Régitine in some countries.
It is used as an intravenous infusion, adjusting the dose according to the lowering of blood pressure, in patients with hypertensive crises due to pheochromocytomas secreting many catecholamines. It is also used on demand during pheochromocytoma surgery.
It has been used, often in combination with papaverine, in intracavernous administration, in the local treatment of impotence or erectile dysfunction.
Its main undesirable effect is a deep and brutal hypotension, especially in case of hypersecretion of catecholamines.
a- phentolamine (Regitine).
b- methyldopa (Aldomet).
c- mannitol (Osmitrol).
d- felodipine (Plendil).
Answer A.
Pheochromocytoma causes excessive production of epinephrine and norepinephrine, natural catecholamines that raise the blood pressure.
Phentolamine, an alpha-adrenergic blocking agent given by I.V. bolus or drip, antagonizes the body’s response to circulating epinephrine and norepinephrine, reducing blood pressure quickly and effectively.
Although methyldopa is an antihypertensive agent available in parenteral form, it isn’t effective in treating hypertensive emergencies.
Mannitol, a diuretic, isn’t used to treat hypertensive emergencies
Felodipine, an antihypertensive agent, is available only in extended-release tablets and therefore doesn’t reduce blood pressure quickly enough to correct hypertensive crisis.
Phentolamine, known since 1950, is a fast-acting, short-acting, high-potency alpha-1-blocking adrenergic with a half-life of 20 minutes. It has been marketed in France for a long time under the name of Régitine but has not been used for many years. it remains marketed under the name Régitine in some countries.
It is used as an intravenous infusion, adjusting the dose according to the lowering of blood pressure, in patients with hypertensive crises due to pheochromocytomas secreting many catecholamines. It is also used on demand during pheochromocytoma surgery.
It has been used, often in combination with papaverine, in intracavernous administration, in the local treatment of impotence or erectile dysfunction.
Its main undesirable effect is a deep and brutal hypotension, especially in case of hypersecretion of catecholamines.
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Endocrine Disorders