about digitoxin, which is false:
- a) Oral bioavaiability 100%***
- b) Protein binding 95%
- c) Half life is 7 days
- d) Mainly hepatic metabolism by microsomal.
The false statement about digitoxin is a) Oral bioavaiability 100%.
Digitoxin has an oral bioavailability of about 70-80%. This means that only 70-80% of a dose of digitoxin that is taken orally is absorbed into the bloodstream. The remaining 20-30% of the dose is excreted in the feces.
The other statements about digitoxin are true:
- Protein binding:
Digoxin is highly protein bound (95%). This means that 95% of digitoxin in the blood is bound to protein. Protein-bound digitoxin is inactive and cannot exert its effects on the body.
- Half-life:
Digoxin has a long half-life of about 7 days. This means that it takes 7 days for half of a dose of digitoxin to be eliminated from the body.
- Metabolism:
Digoxin is mainly metabolized in the liver by microsomal enzymes.
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pharmac