In order to decrease gastric secretion:
1- Histamine.
2- Adrenal steroids.
3- Anticholinergic *** (decrease)
4- Cholinergic. (Increase).
In addition to meals, basal secretion varies between individuals and ranges between 5 and 15 ml / h. Psychoaffective factors may affect secretion. An aggressive and angry person has an increase in secretion and a red lining. A depressed person, has a diminution of its secretion and a pale mucous membrane.
At the time of the meals there is an increase of the maximum secretion 2h after the beginning of the meal. It lasts 4 to 6 hours. It has two characteristics. There is an increase in acid secretion, and control of secretion: neurohorrnona! E and it evolves in three phases. To trigger acid secretion, two substances act on the parietal cell that secretes HCl, parasympathetic Acetylcholine and Gastrin. But these two substances can only act if there is impregnation of histamine (permissive action) .Histamine acts on H2 type receptors in parietal cells.
The first phase of secretion is cephalic:
It is highlighted during fictitious meal experiences. We will recover the meal at the gastric pockets. The secretion is of nervous origin: the parasympathetic secretory center is under the control of
hypothalamus and higher centers.
Through the intermediary of the X the center acts on the different cells: there is a stake of the parasympathetic on the whole of the cells, which is very important on the main cells, little on the bordering cells (secretion of HCl little marked).
But the parasympathetic acts on the release of gastrin which has an important action on the release of HCl.
This cephalic way is a reflex way. It is innate and caused by the palatability (taste) of food, but also conditioned by the sight of food or certain behaviors such as the fixed time of meals in some people.
This phase provides 20 to 25% of the global gastric secretion.
The second phase of secretion is the gastric phase proper:
It is related to the presence of food. It is driven by two nervous and humoral phenomena.
The nervous phenomenon is related to the distention of the stomach. It is a long vegetative reflex. By mechanoreceptors that will stimulate the center and the parasympathetic (same action as before). Foods can also act by short intraparketal reflex pathways.
Humoral phenomena are related to foods that act directly on gastrin cells; essentially proteins that have already undergone digestion (peptones). Gastrin will stimulate the secretion of HCl.
This is the most important phase: 75-80% of the secretion.
The third phase is duodenal:
The arrival of the chyme stimulates two cell types: S cells with secretin and cells K type sensitive to fatty acids more than triglycerides that release the VIP and the GlP (gastric inhibitory peptid) These three substances have an inhibitory effect on gastric secretion.
In addition to meals, basal secretion varies between individuals and ranges between 5 and 15 ml / h. Psychoaffective factors may affect secretion. An aggressive and angry person has an increase in secretion and a red lining. A depressed person, has a diminution of its secretion and a pale mucous membrane.
At the time of the meals there is an increase of the maximum secretion 2h after the beginning of the meal. It lasts 4 to 6 hours. It has two characteristics. There is an increase in acid secretion, and control of secretion: neurohorrnona! E and it evolves in three phases. To trigger acid secretion, two substances act on the parietal cell that secretes HCl, parasympathetic Acetylcholine and Gastrin. But these two substances can only act if there is impregnation of histamine (permissive action) .Histamine acts on H2 type receptors in parietal cells.
The first phase of secretion is cephalic:
It is highlighted during fictitious meal experiences. We will recover the meal at the gastric pockets. The secretion is of nervous origin: the parasympathetic secretory center is under the control of
hypothalamus and higher centers.
Through the intermediary of the X the center acts on the different cells: there is a stake of the parasympathetic on the whole of the cells, which is very important on the main cells, little on the bordering cells (secretion of HCl little marked).
But the parasympathetic acts on the release of gastrin which has an important action on the release of HCl.
This cephalic way is a reflex way. It is innate and caused by the palatability (taste) of food, but also conditioned by the sight of food or certain behaviors such as the fixed time of meals in some people.
This phase provides 20 to 25% of the global gastric secretion.
The second phase of secretion is the gastric phase proper:
It is related to the presence of food. It is driven by two nervous and humoral phenomena.
The nervous phenomenon is related to the distention of the stomach. It is a long vegetative reflex. By mechanoreceptors that will stimulate the center and the parasympathetic (same action as before). Foods can also act by short intraparketal reflex pathways.
Humoral phenomena are related to foods that act directly on gastrin cells; essentially proteins that have already undergone digestion (peptones). Gastrin will stimulate the secretion of HCl.
This is the most important phase: 75-80% of the secretion.
The third phase is duodenal:
The arrival of the chyme stimulates two cell types: S cells with secretin and cells K type sensitive to fatty acids more than triglycerides that release the VIP and the GlP (gastric inhibitory peptid) These three substances have an inhibitory effect on gastric secretion.
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