The materials are surfactant:
Surface agents are absorbent boosters because of their solvent effects and their ability to change the permeability of the membrane. Especially in animals. Polyoxyethylene ethers have been introduced to promote gastrointestinal or rectal absorption of lincomycin, penicillin, cephalosporins and fosfomycin in rats and rabbits. Colorectal alpha-interferon alpha absorption in rats is increased from 3 to 8% by oleic acid ethers of oleic acid And oleic acid glycerides.
Some studies have tested the effects of surface agents on insulin intestinal absorption with variable results. Both rectal and fasting absorption of insulin have been increased by anionic and abiotic surface agents. On the other hand, polyoxyethylene-20-oleyl ether has been caused to reduce the absorption of insulin in humans. [14] The enhanced effect of the drug absorption on the surface agents is related to increased solubility of the drug, alteration of mucous permeability or reduction of resistance to non-moving water layers on the surface of the gastrointestinal membrane. In general, non-porous surface activity has little effect on the structure of the membrane while the activity of the surface of the membrane is associated with cell-cell damage and globet-cell damage. These effects should limit the consideration of surface agents as absorption enhancers, especially for long-term treatment.
Surface agents are absorbent boosters because of their solvent effects and their ability to change the permeability of the membrane. Especially in animals. Polyoxyethylene ethers have been introduced to promote gastrointestinal or rectal absorption of lincomycin, penicillin, cephalosporins and fosfomycin in rats and rabbits. Colorectal alpha-interferon alpha absorption in rats is increased from 3 to 8% by oleic acid ethers of oleic acid And oleic acid glycerides.
Some studies have tested the effects of surface agents on insulin intestinal absorption with variable results. Both rectal and fasting absorption of insulin have been increased by anionic and abiotic surface agents. On the other hand, polyoxyethylene-20-oleyl ether has been caused to reduce the absorption of insulin in humans. [14] The enhanced effect of the drug absorption on the surface agents is related to increased solubility of the drug, alteration of mucous permeability or reduction of resistance to non-moving water layers on the surface of the gastrointestinal membrane. In general, non-porous surface activity has little effect on the structure of the membrane while the activity of the surface of the membrane is associated with cell-cell damage and globet-cell damage. These effects should limit the consideration of surface agents as absorption enhancers, especially for long-term treatment.