Failure of sulfonyl urea drugs and non-response to the body .. Failure in the response of beta cells in the pancreas

The failure of sulfonil urea drugs to continue to maintain a good response to these drugs at the beginning of their use is considered to be one of the disadvantages of sulfonil urea in the treatment of the second type of sugar.
Although the inability to regularly maintain a diet may be responsible for many cases, it is likely that the use of multiple doses that result in elevated levels of long-acting sulfonylurea drugs may result in a lack of response to beta cells in the pancreas.
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