Carcinoid tumors secrete:
- 5HIAA.
Carcinoid tumors originate from the enterocromaffin cells (APUD cells) of the intestine and most commonly occurs in the appendix, terminal ilium and rectum. Presentation may be asymptomatic until metastasis (most cases), appendicitis (10%) or carcinoid syndrome (in5% when there is liver metastasis) as spontaneous flushing on the face and neck, abdominal pain and water diarrhea, cardiac abnormalities and hepatomegally. The tumor secretes a wide variety of amines an peptides including serotonin (5-hydroxytryptamine (5-HT) with its major metabolite 5-hydroxyindoleacetic acid (5-HIAA)), bradykinin, histamine and tachykinins and prostaglandins.
- 5HIAA.
Carcinoid tumors originate from the enterocromaffin cells (APUD cells) of the intestine and most commonly occurs in the appendix, terminal ilium and rectum. Presentation may be asymptomatic until metastasis (most cases), appendicitis (10%) or carcinoid syndrome (in5% when there is liver metastasis) as spontaneous flushing on the face and neck, abdominal pain and water diarrhea, cardiac abnormalities and hepatomegally. The tumor secretes a wide variety of amines an peptides including serotonin (5-hydroxytryptamine (5-HT) with its major metabolite 5-hydroxyindoleacetic acid (5-HIAA)), bradykinin, histamine and tachykinins and prostaglandins.
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Clinical Chemistry