Elimination of Digoxin is mainly by.. Kidney

Elimination of Digoxin is mainly by:

• A. Kidney
• B. Liver
• C. Both
• D. None of the above.

The correct answer is A. Kidney.

Justification:

Digoxin, a cardiac glycoside used to treat various heart conditions, is primarily eliminated from the body through the kidneys. The renal tubules play a crucial role in filtering digoxin from the bloodstream and excreting it in urine.

Details:

• Renal Excretion: The majority of digoxin is excreted unchanged in the urine, primarily through the proximal tubules.
• Hepatic Metabolism: While the liver does play a role in digoxin metabolism, it is a minor pathway compared to renal excretion. The liver converts a small amount of digoxin into inactive metabolites.
• Other Factors: Factors such as kidney function, age, and concurrent medications can influence digoxin elimination. For example, individuals with impaired kidney function may have slower digoxin elimination, leading to increased blood levels and a higher risk of toxicity.

Conclusion:

The primary route of elimination for digoxin is through the kidneys. While the liver does contribute to some extent, renal excretion is the dominant mechanism. Understanding this aspect is crucial for appropriate dosing and monitoring of digoxin therapy.