The concurrent administration (within 1 to 2 hours of dosing) of nislopidine should be avoided wih which of the following?
I- High _ fat meal
II- Grapefruit juice
III- Cocoa
A- I only
B- III only
C- I and II only
D- II and III only
E- I, II and III
Nisoldipine is a molecule of the dihydropyridine family that has a calcium antagonistic effect. It is mainly used as an antihypertensive drug.
Dihydropyridine or dihydroazine is an organic compound derived from pyridine. It consists in fact of a heterocycle with 6 atoms of which one atom of nitrogen (and of carbon) but only partially unsaturated, with only two double bonds (against 3 for pyridine).
The derivatives of dihydropyridine are simply called dihydropyridines, and are a class of calcium antagonist drugs; they are used in the treatment of high blood pressure and angina pectoris.
medications:
Mode of action:
Dihydropyridines block the influx of calcium ions into the smooth muscle cells of the coronary and peripheral arteries, thus preventing the contraction of these vessels. They are thus used as antihypertensives. They act in the same way on the cardiac muscle, but their vascular effect is much greater (other calcium inhibitors like verapamil or diltiazem, on the other hand, have a preferential action on the heart).
Side effects:
The most common side effects of this class of drugs are:
- disorders related to peripheral vasodilatation: headache, vertigo, ankle edema, low blood pressure.
- reflex tachycardia.
- gingival hyperplasia.
Hepatic effects and parkinsonian syndromes2 have also been observed.
Active principles of this class:
- amlodipine.
- barnidipine.
- Clevidipine.
- Felodipine.
- isradipine.
- Lacidipine.
- lercanidipine.
- nicardipine.
- nifedipine.
- nimodipine.
- nisoldipine.
- nitrendipine.
I- High _ fat meal
II- Grapefruit juice
III- Cocoa
A- I only
B- III only
C- I and II only
D- II and III only
E- I, II and III
Nisoldipine is a molecule of the dihydropyridine family that has a calcium antagonistic effect. It is mainly used as an antihypertensive drug.
Dihydropyridine or dihydroazine is an organic compound derived from pyridine. It consists in fact of a heterocycle with 6 atoms of which one atom of nitrogen (and of carbon) but only partially unsaturated, with only two double bonds (against 3 for pyridine).
The derivatives of dihydropyridine are simply called dihydropyridines, and are a class of calcium antagonist drugs; they are used in the treatment of high blood pressure and angina pectoris.
medications:
Mode of action:
Dihydropyridines block the influx of calcium ions into the smooth muscle cells of the coronary and peripheral arteries, thus preventing the contraction of these vessels. They are thus used as antihypertensives. They act in the same way on the cardiac muscle, but their vascular effect is much greater (other calcium inhibitors like verapamil or diltiazem, on the other hand, have a preferential action on the heart).
Side effects:
The most common side effects of this class of drugs are:
- disorders related to peripheral vasodilatation: headache, vertigo, ankle edema, low blood pressure.
- reflex tachycardia.
- gingival hyperplasia.
Hepatic effects and parkinsonian syndromes2 have also been observed.
Active principles of this class:
- amlodipine.
- barnidipine.
- Clevidipine.
- Felodipine.
- isradipine.
- Lacidipine.
- lercanidipine.
- nicardipine.
- nifedipine.
- nimodipine.
- nisoldipine.
- nitrendipine.
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