How can be standardized for intracanal instrument.. width of tip of the blade

How can be standardized for intracanal instrument:
A- length of the blade
B- width of tip of the blade *** 
C- length of the hand
D- size of the hand.

The drug is a pharmaceutical product, obtained or prepared technically, for prophylactic, curative, palliative or diagnostic purposes, capable of inducing functional changes in a living organism, positively or negatively, by a physical, chemical or physicochemical action.
A medicinal product is composed of one or more substances in pharmaceutical form, presented for sale and for clinical (human) and / or veterinary (animal) use, with properties to prevent, relieve or ameliorate disease. health of sick individuals, or change the physiological states.
For use of medicines with animals, see veterinary drugs. In addition, see also medicinal plants (with a guide for use) for herbal medicine, adjuvants (or excipients) and the placebo effect, especially in homeopathy; for the principle of resistance, see drug resistance, disease resistance, and antibiotic resistance.
A drug is manufactured with molecules classified as active, exogenous, organic or inorganic, natural or synthetic active ingredient. The medicinal products are composed of any substance or combination of substances presented as possessing curative or preventive properties for human diseases or their symptoms or which can be used or administered in humans with a medical diagnosis or, by exerting a pharmacological, immunological action or metabolic, restore, correct or alter physiological functions.
A drug may be used or administered for the purpose of restoring, correcting, modifying physiological functions, exerting a pharmacological, immunological or metabolic action, or establishing a medical diagnosis. A drug can also be used to suspend, inhibit or stop physiological functions.
The pharmacist and the pharmacologist are the competent professionals for the use of active pharmaceutical ingredients. The master medication is specifically prepared according to the doctor's prescription when the pharmacological medicine is prepared in advance by the pharmacist.
The term drug means both "cure" but also "poison": the meaning is broader than drug, which indicates the products used for therapeutic purposes to treat various medical conditions, usually diseases. Thus, the concept of medicine has been assigned to different definitions depending on the context in which it is used, sometimes leading to an overlap of meaning with the term drug.
The concept of medicine as a healer was already used by the archaic civilizations of Mesopotamia and Egypt. The term shêrtu, which appears in the manuscripts of the time, has the simultaneous meaning of divine sickness, sin, or punishment. It is only through a catharsis operation, where magical content was attributed to medicine, that the individual would reach the purification of his sins and the restoration of health through the intervention of the gods.
These concepts have influenced the understanding of pathology and therapy for many centuries and persist in some ways to this day. The very word for drugs comes from the Greek word pharmak, which means "what has the power to translate impurities". Among the Greeks, the victims of the sacrifices offered to the gods were called pharmakó, and the food used during the communion ceremonies, phármakon. This last word has come to integrate Greek medical terminology and is considered so far synonymous with the word "drug". For the Greeks, phármakon was what could bring good and evil, sustain life or cause death.
To be marketed (including Italy), a drug must have three characteristics: quality, safety and efficacy. To these may be added limitations imposed by different states in which a drug is marketed or not marketed. Each therapeutic drug typically has one or more active ingredients, intended use, method of use, dosage, contraindications, and side effects, typically described in the so-called packaging insert. In general, the principle of supreme common sense is that each drug is prescribed by the doctor who treats the patient because of its curative effects that overcome the side effects (greater benefits of the disadvantages) with methods and periods of employment that can vary subject because of his personal response to the drug, so close collaboration between the doctor and the patient.
Since taking drugs without the necessary expertise can lead to many side effects until death, a special sales regime is established that varies from country to country. Medications can be divided into three categories: OTC (over the counter, so-called "over-the-counter" medicines), SOP ("without prescription", mainly by the pharmacist's prerogative) and dispensing drugs only on presentation of a prescription. prescription. The latter, which for certain characteristics or for the mode of use could lead to serious risks if used inappropriately, can only be dispensed by a pharmacy approved in pharmacy and presenting the relative written prescription prepared exclusively by a doctor qualified. Certain special classes of drugs, such as drugs and their derivatives, are subject to even greater restrictions (Ministerial Research Receipt, CMA), while certain classes of drugs can only be prescribed by certain specialists (limiting recipe).
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