Endomethasone is a root canal sealer that.. Dissolve in fluid so it weaken the root canal filling

Endomethasone is a root canal  sealer  that:

a- Dissolve in fluid so it weaken the root canal filling.

b- Very toxic contain formaldehyde. 

c- Contain corticosteroids.

D- All the above.***

Common corticosteroid medications: risks of serious problems after only a few days
While the dangers of long-term use of oral corticosteroid medications such as prednisone and cortisone are well known, a US study published in the British Medical Journal aimed to determine the frequency of their prescriptions for short-term use and the effects side effects (sepsis, venous thromboembolism, fractures) associated.
"Corticosteroids are used to treat inflammatory conditions such as asthma, rheumatoid arthritis and inflammatory bowel disease, as well as rashes and muscle aches," reports the New York Times which relays the study.
Akbar K. Waljee of the University of Michigan and his colleagues analyzed the records of 1,548,945 Americans, aged 18 to 64, enrolled in a national health insurance program from 2012 to 2014.
More than one-fifth (327,452, 21%) took oral steroids for one month or less for a variety of conditions, the most common of which were upper respiratory tract infections (eg, bronchitis), low back pain, and the allergies.
Data for the 30 days to five months before they bought these drugs, and then for the next month, were analyzed.
In people taking oral steroids, even at a relatively low dose of 20 mg daily or less:
- the risk of sepsis (blood infection) was 4 times higher;
- that of venous thromboembolism (blood clots), 3 times higher;
- that of bone fracture, 2 times higher.
The risks increased with the doses.
"While steroids may be appropriate in some situations, like many medications, they have side effects," says Dr. Waljee. "We use them perhaps more than we really need. It is important to minimize their use if alternatives exist. "
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Formaldehyde is a chemical substance that occurs at room temperature in the form of a suffocating and flammable colorless gas. It is often marketed in liquid form commonly called formalin. It is also known as methanal or formaldehyde.

Exposures to formaldehyde are both professional and environmental. They occur in more than a hundred professional environments and a wide variety of business sectors: veterinary, cosmetic, medical, industry, agriculture ... More than 190,000 workers today would be exposed to formaldehyde. The strongest exposures are in the health sectors (anatomopathologists), agriculture, chemical industry and funeral directors (embalmers), but also in the manufacture of paper or some resins. Formaldehyde is one of the pollutants of the air of places of life: offices, housing ...

Formaldehyde and cancer:

IARC has classified carcinogenic formaldehyde in humans (group 1) in 2004 (IARC 2006). The working group felt that there was sufficient evidence that formaldehyde causes nasopharyngeal cancer (based on consistent epidemiological studies in the workplace).

In 2009, a new IARC working group further concluded that there are sufficient indications of carcinogenicity in humans for leukemia and more specifically for myeloid leukemia in humans are sufficient (Hauptmann, 2009; Zhang , 2009). Indications of carcinogenicity in humans for nasal fossae and sinus of the face have been considered limited (Baan, 2009).

The US National Toxicology Program reports in its 12th report on carcinogens published in June 2011 that there is sufficient evidence of the carcinogenicity of formaldehyde provided by human studies (National Toxicology Program, 2011).

Although in Europe, the regulatory classification of formaldehyde remains "carcinogenic category 3" (possible carcinogen in humans), following a more severe French proposal, this classification is currently being revised. In France, the decree of July 13, 2006, added the works exposing formaldehyde to the list of carcinogenic processes of the Labor Code. The regulations concerning the carcinogenic risk must therefore be applied.

In its report on the health risks related to the presence of formaldehyde in professional environments, Afsset reports on epidemiological studies highlighting risk levels of nasopharyngeal cancer associated with various long-term aerial exposures and corresponding to sectors of professional activity. The increased risk is associated with exposure to a peak repeat of at least 5 mg / m3 (Afsset, 2009).

Since 2009, nasopharyngeal cancer has been recognized as an occupational disease (Table 43 bis relating to cancerous diseases caused by formaldehyde), subject to a 5-year exposure linked to certain works (preparation of formalin, use in certain laboratories , varnishing of parquet floors, fire extinguishing works ...). The waiting period has been set at 40 (see table 43 bis).

Work involving exposure to formaldehyde is now part of the carcinogenic risk activities in labor law (Decree of the General Directorate of Labor of 13 July 2006). Companies are thus obliged to justify actions to substitute their use for a product that is not harmful to health or to protect workers.

Uses and routes of exposure:

Extremely common, formaldehyde is used as a disinfectant or biocide (germicide, insecticide, fungicide), as a fixative and as a binder in resins. It is found in DIY products, maintenance, in wall coverings, floors or furniture, in plastics, in tobacco smoke ... It is used in the composition of 5% of chemicals.

Toxic effects are exerted by air and locally by direct exposure: exposure of the respiratory tract, ocular pathways, ears, intestinal organs and skin. Skin exposure may, for example, cause an allergic reaction in sensitized individuals.

Concentrations of formaldehyde in the indoor air of dwellings:

Formaldehyde is frequently present in the indoor air of homes where the building itself, its equipment, its decoration (wall coverings, floor coverings, furniture ...), domestic products emit it at low levels (release).

Its presence in the air of housing is considered important in France, according to the measurements made in recent years: 10% of houses are "multipolluted" in France and 4% would have formaldehyde concentrations greater than or equal to the proposed guide value by Afsset for formaldehyde, for two-hour exposures (national study conducted in 2006 by the Observatory of indoor air quality). The concentration of formaldehyde may be higher in indoor air than in outdoor air.

Indoor air quality: guide values ​​and low emissivity products:

In July 2007, Afsset proposed guiding values ​​for formaldehyde, taking into account knowledge of air pollution in living areas identified in collaboration with CSTB: a guide value of 10 μg / m3 (10 micrograms per cubic meter) for long-term exposure. The High Committee of Public Health (HCSP) proposes to retain:

- 10 μg / m3 (10 micrograms per cubic meter) as target value to be achieved in 10 years

- 30 μg / m3 as a "benchmark" value below which no specific corrective action in existing buildings is recommended; while taking care to take advantage of renovations or furniture changes to choose the least emissive materials and thus promote the gradual evolution towards the objective of 10 μg / m3.

Regarding the reduction of pollutants at source in itself, AFSSET has also developed a procedure (updated in 2009) to identify and promote building materials and decorative products (solid and liquid) "low emissivity ".

INPES has published a guide on indoor air pollution with advice on identifying sources and how to reduce them. It recommends, for example, to ventilate the dwellings, 10 minutes a day even in the winter, and to ventilate more often during specific activities, to not hinder the operation of the ventilation systems and to maintain them regularly.

Recent developments:

In its report "Cancers and environment" of July 2009, Afsset issued recommendations on exposure to formaldehyde in professional and environmental environments. These are preventive actions (substitution of formaldehyde, concentration limits ...), surveillance of exposed workers and improvement of medical knowledge.

Improving indoor air quality is one of the priorities of the second national health and environment plan (PNSE 2). In this context, specific actions to reduce formaldehyde emissions are in progress:

- the restriction of the use of formaldehyde for certain uses (construction products, wood particle board ...), within the framework of the European regulation R.E.A.Ch

- the introduction of mandatory labeling for pollutant emissions (especially of formaldehyde) of construction and decoration products and sources of emissions into indoor air.

ANSES was seized on May 11, 2011 by the General Directorate for Risk Prevention of a request for an opinion on a draft decree relating to guide values ​​for indoor air (VGAI) for formaldehyde and benzene adding Article R. 221-29 in the code of the environment. ANSES proposed to retain the existing guide-values ​​for the premises of certain establishments open to the public (schools, crèches, health establishments, covered sports facilities): 30 μg / m3 for a long-term exhibition as a guide value to count from January 1, 2015; 10 μg / m3 for long-term exposure as a guide value as of January 1, 2023. These values ​​are below the guideline value of 100 μg / m3 proposed by WHO. They will be regularly revised, in particular according to the results of indoor air quality measurement campaigns and progress on the substitution of formaldehyde by other products (ANSES, 2011).