Reasons for the ineffectiveness of insulin
There are certain reasons lead to the lack of response from diabetic insulin for treatment in some cases, including:
- Injury to any microbe, as the microbes reduce the resistance of the body and especially the patients who suffer from lack of blood sugar control.
- Obese diabetic needs to a large dose of insulin.
- Gigantism's disease, which leads to increased secretion of growth hormone.
- Various liver diseases which lead to a lack of effectiveness of insulin.
- Causes immune automatically lead to reduced effectiveness of insulin due to the formation of antibodies to insulin.
- Expiration & insulin user.
What is insulin?
Insulin is a hormone responsible for controlling blood glucose levels, as it allows glucose to enter cells to provide us with energy. There are several different types and forms of insulin used medically, as it is prescribed to patients according to their health needs. The main function of insulin used as a treatment is to control the level of glucose (sugar) in the blood in patients with diabetes.
Do all diabetics need insulin?
If you are diagnosed with type 1 diabetes, you will be prescribed insulin as the body needs it to control blood glucose levels. Some people with type 2 diabetes also need insulin if their blood glucose cannot be controlled in any other way. Control of blood glucose level is critical as too high or too low a glucose level can result in severe life-threatening symptoms.
How is insulin used?
You will be given instructions on the use of insulin by your diabetes team, and you will be provided with all necessary information on how to use insulin and how much to take. In general, it can be indicated that the use of insulin is in one of the following ways: syringes, an insulin pen, or an insulin pump.
How is insulin transported and stored?
Insulin must be stored in an appropriate manner to ensure its effectiveness, and care must be taken to have the dose you need with you at all times. Tips and recommendations for insulin storage and transportation include:
- Do not expose insulin to very hot or very cold temperatures
- Use the temperature control device provided by your diabetes care team when administering insulin
- Never store insulin in a car or expose it to the sun
- Insulin should not be kept in the freezer (refrigerator freezer).
- Check the expiration date on the insulin package, and inspect for any abnormal signs in the package to ensure that it has not been tampered with, leading to damage or spoilage of its contents.
- Ensure that syringes and needles are stored properly and disposed of in a safe and appropriate manner, as instructed by your diabetes team
What is a major factor in errors related to insulin?
In terms of the forms of insulin administration error, the most common error types were the wrong dose, omitted or delayed insulin. The current common known contributing factors leading to insulin error were transcribing errors, drug calculation mistakes, non-adherence to protocols, and failure in communication.
What are three possible causes of insulin resistance?
Obesity (being significantly overweight and belly fat), an inactive lifestyle, and a diet high in carbohydrates are the primary causes of insulin resistance. Some women develop insulin resistance while they are pregnant. This is called gestational diabetes. Certain diseases are associated with insulin resistance.
Why is insulin important for the body's effective use of glucose?
Insulin helps keep the glucose in your blood within a normal range. It does this by taking glucose out of your bloodstream and moving it into cells throughout your body. The cells then use the glucose for energy and store the excess in your liver, muscles, and fat tissue.
Why is insulin ineffective in type 2 diabetes?
In type 2 diabetes, the pancreas makes insulin, but the cells don't respond to it as they should. This is called insulin resistance. When glucose can't get into cells, the blood sugar level rises. Then the pancreas works harder to make even more insulin.
When does insulin become ineffective?
Note: Insulin loses some effectiveness when exposed to extreme temperatures. The longer the exposure to extreme temperatures, the less effective the insulin becomes. This can result in loss of blood glucose control over time.
What factors are associated with insulin resistance not being able to use insulin effectively?
The two main factors that seem to contribute to insulin resistance are excess body fat, especially around your belly, and a lack of physical activity. People who have prediabetes and Type 2 diabetes usually have some level of insulin resistance. People with Type 1 diabetes can also experience insulin resistance.
What happens if you have insulin antibodies?
If you have IgG and IgM antibodies against insulin, your body reacts as if the insulin in your body is a foreign protein that needs to be removed. This may make insulin less effective, or not effective at all. This is because the antibody prevents the insulin from working the right way in your cells.
What makes insulin ineffective?
The pancreas pumps out more insulin to get blood sugar into cells. Over time, cells stop responding to all that insulin—they've become insulin resistant. The pancreas keeps making more insulin to try to make cells respond. Eventually, the pancreas can't keep up, and blood sugar keeps rising.
