The second generation of sulfonyl urea drugs .. Caution in patients with heart disease or in elderly patients

Strongly used second-generation sulfonil urea drugs such as gliboride, glybizide, and glymaride should be used with caution in patients with heart disease or in older patients who are at higher risk for severe hypoglycaemia.
Diabetics with type 2 diabetes who did not respond to treatment using tulipiotamide or tulazamide may respond to treatment using the stronger first-generation drugs of sulfonylurea (such as chlorpromamide) or a second-generation drug.
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