Ester type of LA secreted by?
- A. Liver only.
- B. Kidney.
- C. Lung.
- D. Liver and plasma.
While ester-type local anesthetics (LAs) are primarily metabolized by the liver, the correct answer is not A. Liver only.
Here's a breakdown:
- Ester-type LAs:
Examples include procaine, cocaine, benzocaine, and chloroprocaine.
- Metabolism:
They are hydrolyzed, meaning broken down by water, by an enzyme called pseudocholinesterase, which is present in various tissues throughout the body.
- Main site of metabolism:
While the liver contains high levels of pseudocholinesterase, it is not the only site.
- Other sites:
Significant amounts of pseudocholinesterase are also found in the plasma, making it another contributor to the breakdown of ester-type LAs.
Therefore, the most accurate answer is D. Liver and plasma. Both contribute to the metabolism of ester-type local anesthetics.
Additional Points:
Here are some additional points to remember:
- Individual variations:
Some individuals may have a genetic deficiency in pseudocholinesterase, leading to prolonged effects of ester-type LAs.
- Safety concerns:
Due to potential allergic reactions and the possibility of rapid breakdown due to individual variations in enzyme activity, ester-type LAs are used less frequently than amide-type LAs in clinical settings.
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