Characterized patients with type II diabetes low number of insulin receptors, which may explain the weakness of the effect of insulin in these patients or what is called insulin resistance. And there are studies that suggest that chronic use of these drugs increases the correlation with insulin receptor tissue by increasing the number of receptors on the walls of the cells of the liver, and therefore increases the effectiveness of insulin released from the beta cells in these patients or insulin given by injection. In any case, the mechanism has not been proven correct after as giving drugs sulfonylureas in patients with type I diabetes and who do not have insulin, this did not improve the level of sugar in their blood, and also did not lead these drugs to increase the effectiveness of insulin given by injection, or increase the number of receptors that are associated with insulin.
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sulfonylureas