Sunday, December 24, 2023

Nystatin - a deadly fungal Fungicidal.. Stomatitis mildew. Treat mastitis in cows. Inflammation of the outer ear mildew in dogs



Nystatin 

Against the types of foreign-fungal

Mechanism of Action ß Has high affinity for union with receptors Ergosterol Located on the cell membrane of the fungi and this leads to change permeability of fungal bacteria which leads to escape potassium and cellular components.


Uses:

  • Stomatitis innate - Treatment of mastitis in cows, caused by candida (300,000 units / per the udder day to box for 3 days).
  • Inflammation of the outer ear mildew in dogs. 
Dosage: dogs and cats 100,000 units / kg. Nystatin of injecting poisonous drugs.

  • Nystatin belongs to the polynomial group, which is associated with ergosterol, the main component of the cytoplasmic membrane of the fungal cell, which changes the permeability of the cell wall and causes holes in the membrane.
  • This drug is well absorbed by proper skin and mucous membranes, while it is not absorbed by the intestine when given orally.
  • White Candida breakfasts appear to be a good response to nystatin therapy, so it is used in oral pharyngeal candidiasis, gastrointestinal candidiasis, vesicular vagina and vaginitis, candidiasis, cutaneous candidiasis.

Pharmaceutical Information:

  • The medicine is in the form of oral tablets, oral fluid (drink and fall), cream and ointment for external use, vaginal tablets, powder.
  • In oral oral pharyngeal disease, oral pharyngeal disease is given four times a day (100 000 for preterm infants, 200,000 for infants and 400,000 for children and adults), with oral dose retention as long as possible before swallowing). Treatment should be continued for 48 hours At least after symptoms disappear around the mouth.
  • Gastrointestinal candidiasis is given in the form of oral tablets 3 times daily (500000-1000000 units) and treatment should be continued for at least 48 hours after clinical improvement.
  • It is also applied topically two to three times a day in the form of a skin lotion (ointment, cream or powder for external use) in skin candidiasis, skin and mucosal infections, and the application must continue until full recovery.
  • In vaginal and vaginal inflammation of the Candida, one vaginal tablet (100,000 units) is used daily for two weeks.